Tetrahydrouridine

Tetrahydrouridine

SCHEMBL172272

O=C1N[C@H](O)CCN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CDA P32320 13/20 0.66
MAPT P10636 1/20 0.46
SLC28A1 O00337 1/20 0.45
SLC28A2 O43868 1/20 0.45
SLC29A1 Q99808 1/20 0.45
SLC28A3 Q9HAS3 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrouridine SCHEMBL587704 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
Tetrahydrouridine SCHEMBL127270 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
Tetrahydrouridine SCHEMBL171865 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
Tetrahydrouridine SCHEMBL11761038 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
Tetrahydrouridine SCHEMBL11759489 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
Tetrahydrouridine SCHEMBL14133787 1.00 CDA (0.66) CDAMAPTSLC28A1SLC28A2SLC29A1
SCHEMBL10069547 0.87 CDA (0.59) CDAMAPT
SCHEMBL12338486 0.87 CDA (0.55) CDAMAPT
SCHEMBL12338454 0.87 CDA (0.59) CDAMAPT
SCHEMBL10069752 0.87 CDA (0.59) CDAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4599498-A1 ELECTROLYTES COMPRISING THIOAMIDES FOR USE IN ELECTROCHEMICAL BATTERIES THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2025-08-13 EP claimed
EP-3960182-B1 COMPOSITIONS CONTAINING DECITABINE, 5-AZACYTIDINE AND TETRAHYDROURIDINE AND USES THEREOF EPIDESTINY INC (US) 2025-03-19 EP claimed
EP-4370127-A2 A METHOD OF TREATING CANCER OR A BLOOD DISORDER Ebrahem, Quteba (US) 2024-05-22 EP claimed
WO-2024076361-A1 ELECTROLYTES COMPRISING THIOAMIDES FOR USE IN ELECTROCHEMICAL BATTERIES THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2024-04-11 WO claimed
US-20240113339-A1 ELECTROLYTES COMPRISING THIOAMIDES FOR USE IN ELECTROCHEMICAL BATTERIES THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES 2024-04-04 US claimed
US-20230142647-A1 METHOD OF TREATING CANCER OR A BLOOD DISORDER EBRAHEM QUTEBA (US) 2023-05-11 US claimed
US-20230055298-A1 COMPOSITIONS COMPRISING 2'-DEOXYCYTIDINE ANALOGS AND USE THEREOF FOR THE TREATMENT OF SICKLE CELL DISEASE, THALASSEMIA, AND CANCERS ADIMABIO LLC 2023-02-23 US claimed
WO-2023287797-A2 A METHOD OF TREATING CANCER OR A BLOOD DISORDER EBRAHEM QUTEBA (US) 2023-01-19 WO claimed
EP-3960182-A1 COMPOSITIONS CONTAINING DECITABINE, 5-AZACYTIDINE AND TETRAHYDROURIDINE AND USES THEREOF Epidestiny, Inc. (US) 2022-03-02 EP claimed
US-20260076988-A1 TIMED ALTERNATE ADMINISTRATION OF DECITABINE AND 5-AZACYTIDINE FOR CANCER TREATMENT CLEVELAND CLINIC FOUND (US) 2026-03-19 US disclosed
CN-121571203-A Cerium-based polyoxometallate supported metal organic framework composite material, preparation method thereof and application thereof in detecting antioxidant content 河南大学 2026-02-27 CN disclosed
EP-4462543-B1 AN ELECTROLYTE ADDITIVE AND A PREPARATION METHOD THEREFOR, AN ELECTROLYTE AND A LITHIUM ION BATTERY JIANGSU ZENERGY BATTERY TECH GROUP CO LTD (CN) 2026-01-21 EP disclosed
EP-3976054-B1 TIMED ADMINISTRATION OF DECITABINE AND 5-AZACYTIDINE FOR CANCER TREATMENT CLEVELAND CLINIC FOUND (US) 2026-01-07 EP disclosed
US-12486292-B2 Prodrug platform useful to deliver amines, amides and phenols Changchun Changcheng Pharmaceutical Technology Co., LTD (CN) 2025-12-02 US disclosed
US-20140186335-A1 Certain Compounds, Compositions and Methods EISAI INC. (US) 2014-07-03 US disclosed
US-8268800-B2 Certain compounds, compositions and methods EISAI INC. (US) 2012-09-18 US disclosed
EP-2447272-A1 2'-Fluoro-2'-deoxytetrahydrouridines as cytidine deaminase inhibitors Eisai Inc. (US) 2012-05-02 EP disclosed
EP-2207786-B1 2'-FLUORO-2'-DEOXYTETRAHYDROURIDINES AS CYTIDINE DEAMINASE INHIBITORS EISAI INC (US) 2012-03-07 EP disclosed
US-20090137521-A1 Certain Compounds, Compositions and Methods TAIHO PHARMACEUTICAL CO., LTD. (JP) 2009-05-28 US disclosed
WO-2009052287-A1 2 ' -FLU0R0-2 ' -DEOXYTETRAHYDROURIDINES AS CYTIDINE DEAMINASE INHIBITORS EISAL CORPORATION OF NORTH AMERICA (US) 2009-04-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140186335-A1 Certain Compounds, Compositions and Methods DUT, TYMP, DPYD CDA 134/4885MAPT 1627/4885SLC28A1 1165/4885
US-20090137521-A1 Certain Compounds, Compositions and Methods DUT, TYMP, DPYD CDA 134/4885MAPT 1627/4885SLC28A1 1165/4885
US-20260076988-A1 TIMED ALTERNATE ADMINISTRATION OF DECITABINE AND 5-AZACYTIDINE FOR CANCER TREATMENT DCTD, ADA, DUT CDA 4/4885MAPT 4571/4885SLC28A1 776/4885
US-12486292-B2 Prodrug platform useful to deliver amines, amides and phenols GOT1, PAM, GLS2 CDA 78/4885MAPT 376/4885SLC28A1 227/4885
US-20230055298-A1 COMPOSITIONS COMPRISING 2'-DEOXYCYTIDINE ANALOGS AND USE THEREOF FOR THE TREATMENT OF SICKLE CELL DISEASE, THALASSEMIA, AND CANCERS TYMP, HBZ, HBB CDA 4/4885MAPT 3834/4885SLC28A1 171/4885
US-20230142647-A1 METHOD OF TREATING CANCER OR A BLOOD DISORDER XPO1, NPM1, XPOT CDA 152/4885MAPT 2821/4885SLC28A1 169/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.