Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877994 | 0.87 | POLB (0.44) | TSHRNPC1SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL5877389 | 0.85 | NPC1 (0.46) | TSHRNPC1SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL5876981 | 0.83 | F11 (0.52) | KDM4EPOLBLMNAHPGDMEN1 | |
| SCHEMBL5877978 | 0.83 | AVPR1B (0.49) | MEN1KMT2ACYP2D6KCNH2GHSR | |
| SCHEMBL5877284 | 0.83 | ATM (0.58) | TSHRSMN1; SMN2ATMPOLBLMNA | |
| SCHEMBL6308557 | 0.82 | NPSR1 (0.52) | TSHRNPC1SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL5877563 | 0.82 | F11 (0.50) | SMN1; SMN2RAB9AKDM4ELMNAHPGD | |
| SCHEMBL5877069 | 0.81 | F11 (0.49) | MEN1KMT2ACYP2D6KCNH2GHSR | |
| SCHEMBL5877712 | 0.81 | AVPR1B (0.51) | GHSR | |
| SCHEMBL5877695 | 0.80 | AVPR1B (0.46) | LMNAHTTMAPTNPSR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |