Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877389 | 0.88 | NPC1 (0.46) | POLBMEN1KMT2AATMCNR2 | |
| SCHEMBL5877496 | 0.87 | TSHR (0.48) | POLBMEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL5877284 | 0.85 | ATM (0.58) | POLBATMABCC1SMN1; SMN2LMNA | |
| SCHEMBL5876953 | 0.83 | ABCC1 (0.50) | MEN1KMT2AABCC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5877626 | 0.82 | ABCC1 (0.52) | MEN1KMT2AABCC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5877726 | 0.82 | ATM (0.43) | POLBMEN1KMT2AATMCNR2 | |
| SCHEMBL5877811 | 0.82 | ABCC1 (0.46) | KMT2AABCC1CYP2D6GHSRTP53 | |
| SCHEMBL6308164 | 0.81 | JAK2 (0.44) | POLBATMSMN1; SMN2NPC1RAB9A | |
| SCHEMBL5877732 | 0.81 | ABCC1 (0.52) | MEN1KMT2AABCC1ALDH1A1CYP2D6 | |
| SCHEMBL5877867 | 0.80 | GHSR (0.54) | ABCC1TSHRCYP2D6GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |