Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UMPS | P11172 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27588394 | 0.90 | UMPS (0.44) | UMPSTDP1SIRT3LMNASMN1; SMN2 | |
| SCHEMBL6784339 | 0.90 | UMPS (0.44) | UMPSTDP1SIRT3LMNASMN1; SMN2 | |
| SCHEMBL27606205 | 0.90 | UMPS (0.44) | UMPSTDP1SIRT3LMNASMN1; SMN2 | |
| SCHEMBL6790961 | 0.90 | UMPS (0.44) | UMPSTDP1SIRT3LMNASMN1; SMN2 | |
| SCHEMBL8973945 | 0.89 | PYGL (0.43) | PYGLSLC5A2 | |
| SCHEMBL6934645 | 0.84 | SLC5A2 (0.42) | ALDH1A1GLAKDM4EGAASLC5A2 | |
| SCHEMBL6784360 | 0.84 | SLC5A2 (0.42) | ALDH1A1GLAKDM4EGAASLC5A2 | |
| SCHEMBL6791901 | 0.84 | SLC5A2 (0.42) | ALDH1A1GLAKDM4EGAASLC5A2 | |
| SCHEMBL15968709 | 0.81 | SLC5A2 (0.46) | UMPSPYGLSLC5A2 | |
| SCHEMBL6790763 | 0.78 | PYGL (0.41) | PYGLSLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060094670-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases | SAUVE ANTHONY A | 2006-05-04 | — | — | US | disclosed |
| US-20060089318-A1 | Inhibitors of adp-ribosyl transferases, cyclases, and hydrolases | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY | 2006-04-27 | — | — | US | disclosed |
| US-7022680-B2 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2006-04-04 | — | — | US | disclosed |
| EP-1513402-A1 | IMPROVED INHIBITORS OF ADP-RIBOSYL TRANSFERASES, CYCLASES, AND HYDROLASES | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2005-03-16 | — | — | EP | disclosed |
| US-20030229033-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. | 2003-12-11 | — | — | US | disclosed |
| WO-2003101198-A1 | IMPROVED INHIBITORS OF ADP-RIBOSYL TRANSFERASES, CYCLASES, AND HYDROLASES | ALBERT EINSTEIN COLLEGE OF MEDICINE OF ZESHIVA UNIVERSITY (US) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094670-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases | CD38, NAMPT, ADPRS | UMPS 244/4885TDP1 557/4885SIRT3 90/4885 |
| US-20060089318-A1 | Inhibitors of adp-ribosyl transferases, cyclases, and hydrolases | CD38, ADPRS, PARP11 | UMPS 298/4885TDP1 384/4885SIRT3 44/4885 |
| US-20030229033-A1 | Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases | CD38, ADPRS, NNT | UMPS 267/4885TDP1 549/4885SIRT3 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.