Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | FPR3 | P25089 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508195 | 0.86 | KDM4E (0.57) | KDM4EPKMTGFBR1BRD4MAPT | |
| SCHEMBL22716661 | 0.85 | KDM4E (0.61) | KDM4EPKMTGFBR1BRD4GPR119 | |
| SCHEMBL30703662 | 0.85 | KDM4E (0.61) | KDM4EPKMTGFBR1BRD4GPR119 | |
| SCHEMBL5897576 | 0.84 | HDAC3 (0.52) | BRD4MAPTL3MBTL1KDM1AHPGD | |
| SCHEMBL17796229 | 0.81 | KDM4E (0.72) | KDM4EPKMTGFBR1BRD4MAPT | |
| SCHEMBL14447471 | 0.80 | PTPN2 (0.62) | KDM4EPKMGPR119NAMPTHDAC3 | |
| SCHEMBL8000757 | 0.79 | KDM4E (0.80) | KDM4EPKMTGFBR1BRD4GPR119 | |
| SCHEMBL17796159 | 0.78 | KDM4E (0.64) | KDM4EPKMTGFBR1GPR119KDM1A | |
| SCHEMBL4514614 | 0.78 | KDM4E (0.59) | KDM4EPKMTGFBR1MAPTL3MBTL1 | |
| SCHEMBL13848219 | 0.77 | TGFBR1 (0.50) | KDM4EPKMTGFBR1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105508-B1 | Integrin receptors antagonists | ABBOTT GMBH & CO. KG (DE) | 2006-09-12 | — | — | US | disclosed |
| US-20040259864-A1 | Substituted pyrimidinone derivatives as ligands of integrin receptors | ABBOTT GMBH & CO. KG (DE) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259864-A1 | Substituted pyrimidinone derivatives as ligands of integrin receptors | ITGB3, ITGA5, ITGB5 | KDM4E 3060/4885PKM 3799/4885TGFBR1 425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.