Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.80 |
| ▸ | PKM | P14618 | 1/20 | 0.80 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26131403 | 0.89 | KDM4E (1.00) | KDM4EPKMTGFBR1BRD4GPR119 | |
| SCHEMBL7993458 | 0.84 | ALDH1A1 (0.56) | KDM4EPKMALDH1A1GLAALOX12 | |
| SCHEMBL2584410 | 0.80 | ALDH1A1 (0.65) | KDM4EALDH1A1GLAALOX12KMT2A | |
| SCHEMBL5879547 | 0.79 | KDM4E (0.61) | KDM4EPKMTGFBR1BRD4GPR119 | |
| SCHEMBL4514614 | 0.79 | KDM4E (0.59) | KDM4EPKMTGFBR1ALDH1A1KEAP1 | |
| SCHEMBL15661860 | 0.79 | KDM4E (0.80) | KDM4EPKMTGFBR1GPR119KMT2A | |
| SCHEMBL13947430 | 0.79 | KDM4E (0.80) | KDM4EPKMGPR119TP53KMT2A | |
| SCHEMBL3036555 | 0.79 | KDM4E (0.80) | KDM4EPKMTGFBR1GPR119KMT2A | |
| SCHEMBL4508195 | 0.78 | KDM4E (0.57) | KDM4EPKMTGFBR1BRD4GPR119 | |
| SCHEMBL7090271 | 0.78 | KDM4E (0.71) | KDM4EPKMTGFBR1BRD4GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001064675-A1 | CONDENSED THIAZOLAMINES AND THEIR USE AS NEUROPEPTIDE Y5 ANTAGONISTS | NOVARTIS AG (CH) | 2001-09-07 | — | — | WO | disclosed |