Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hippuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.66 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | PTPRC | P08575 | 2/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22030672 | 0.98 | GAA (0.68) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL7486 | 0.98 | GAA (0.68) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL428479 | 0.98 | GAA (0.68) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL1179259 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL21569381 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL3448563 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL7796688 | 0.96 | KDM4E (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL7398337 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL11656206 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL1458080 | 0.96 | MAPT (0.66) | MAPTKDM4EHIF1ASLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161365-A1 | Phosphate-Binding Magnesium Salts And Uses Thereof | CURRAX PHARMACEUTICALS LLC | 2018-06-14 | — | — | US | claimed |
| US-9889157-B2 | Phosphate-binding magnesium salts and uses thereof | CYPRESS PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | claimed |
| US-20170202875-A1 | Phosphate-Binding Magnesium Salts And Uses Thereof | WILMINGTON SAVINGS FUND SOCIETY, FSB | 2017-07-20 | — | — | US | claimed |
| US-9610267-B2 | Phosphate-binding magnesium salts and uses thereof | CYPRESS PHARMACEUTICALS, INC. (US) | 2017-04-04 | — | — | US | claimed |
| US-20160256420-A1 | Phosphate-Binding Magnesium Salts And Uses Thereof | WILMINGTON SAVINGS FUND SOCIETY, FSB | 2016-09-08 | — | — | US | claimed |
| US-9339481-B2 | Phosphate-binding magnesium salts and uses thereof | CYPRESS PHARMACEUTICALS, INC. (US) | 2016-05-17 | — | — | US | claimed |
| EP-2416786-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | Cypress Pharmaceutical, Inc. (US) | 2012-02-15 | — | — | EP | claimed |
| WO-2010117370-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | claimed |
| US-20090269399-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICAL, INC. (US) | 2009-10-29 | — | — | US | claimed |
| CN-1032155-C | Road reflective sign and manufacturing method thereof | CHEN HONGCHUN (CN) | 1996-06-26 | — | — | CN | claimed |
| EP-0515743-A1 | Process for manufacturing road warning device for divided driveway | Chen, Hung-Chun (TW) | 1992-12-02 | — | — | EP | claimed |
| CN-1062571-A | Road warning device and manufacturing method thereof | CHEN HONGCHUN (CN) | 1992-07-08 | — | — | CN | claimed |
| EP-3684740-B1 | ALUMINA SINTERED BODY | SHOWA DENKO KK (JP) | 2021-07-28 | — | — | EP | disclosed |
| EP-3848340-A1 | ABRASIVE GRAIN AND GRINDING WHEEL | Showa Denko K.K. (JP) | 2021-07-14 | — | — | EP | disclosed |
| US-11041102-B2 | Alumina sintered body, abrasive grain, and grinding wheel | SHOWA DENKO K.K. (JP) | 2021-06-22 | — | — | US | disclosed |
| CN-111263740-B | Alumina sintered body, abrasive grain, and grinding wheel | 昭和电工株式会社 | 2021-06-11 | — | — | CN | disclosed |
| CN-1032155-C | Road reflective sign and manufacturing method thereof | CHEN HONGCHUN (CN) | 1996-06-26 | — | — | CN | disclosed |
| US-5173099-A | Process for manufacturing road warning device for divided driveway | CHEN HUNG CHUN (TW) | 1992-12-22 | — | — | US | disclosed |
| EP-0515743-A1 | Process for manufacturing road warning device for divided driveway | Chen, Hung-Chun (TW) | 1992-12-02 | — | — | EP | disclosed |
| CN-1062571-A | Road warning device and manufacturing method thereof | CHEN HONGCHUN (CN) | 1992-07-08 | — | — | CN | disclosed |