Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 4/20 | 0.72 |
| ▸ | PRKCG | P05129 | 4/20 | 0.72 |
| ▸ | PRKCB | P05771 | 4/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.72 |
| ▸ | PRKCA | P17252 | 4/20 | 0.72 |
| ▸ | PRKCH | P24723 | 4/20 | 0.72 |
| ▸ | PRKCI | P41743 | 4/20 | 0.72 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.72 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.72 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.72 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.72 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.72 |
| ▸ | PRKACA | P17612 | 3/20 | 0.72 |
| ▸ | PRKACG | P22612 | 3/20 | 0.72 |
| ▸ | PRKACB | P22694 | 3/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10988523 | 0.87 | ROCK2 (0.79) | PRKD3PRKCGPRKCBCYP3A4PRKCA | |
| SCHEMBL26584304 | 0.86 | ROCK2 (0.77) | PRKD3PRKCGPRKCBCYP3A4PRKCA | |
| SCHEMBL29770053 | 0.86 | ROCK2 (0.77) | PRKD3PRKCGPRKCBCYP3A4PRKCA | |
| SCHEMBL10985139 | 0.86 | ROCK2 (0.77) | PRKD3PRKCGPRKCBCYP3A4PRKCA | |
| SCHEMBL6916059 | 0.86 | ROCK2 (0.77) | PRKD3PRKCGPRKCBCYP3A4PRKCA | |
| SCHEMBL7315948 | 0.85 | PRKD3 (0.74) | PRKD3PRKCGPRKCBCYP3A4PRKCA | |
| Hydrochloric Acid SCHEMBL9617961 | 0.85 | ROCK2 (0.77) | PRKD3PRKCGPRKCBCYP3A4PRKCA | |
| SCHEMBL1272907 | 0.84 | PRKD3 (1.00) | PRKD3PRKCGPRKCBCYP3A4PRKCA | |
| SCHEMBL30422637 | 0.84 | PRKD3 (1.00) | PRKD3PRKCGPRKCBCYP3A4PRKCA | |
| SCHEMBL29968762 | 0.84 | PRKD3 (1.00) | PRKD3PRKCGPRKCBCYP3A4PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091200-B2 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | SYNTEX U.S.A. LLC (US) | 2006-08-15 | — | — | US | disclosed |
| US-6900220-B2 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | SYNTEX (U.S.A.) LLC (US) | 2005-05-31 | — | — | US | disclosed |
| US-20050107365-A1 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | BECKER CYRUS K (US) | 2005-05-19 | — | — | US | disclosed |
| EP-1363899-B1 | QUINAZOLONE DERIVATIVES AS ALPHA 1A/B ADRENERGIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-05-11 | — | — | EP | disclosed |
| EP-1363899-A1 | QUINAZOLONE DERIVATIVES AS ALPHA 1A/B ADRENERGIC RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2003-11-26 | — | — | EP | disclosed |
| US-20030069230-A1 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | SYNTEX (U.S.A.) LLC | 2003-04-10 | — | — | US | disclosed |
| WO-2002053558-A1 | QUINAZOLONE DERIVATIVES AS ALPHA 1A/B ADRENERGIC RECEPTOR ANTAGONISTS | F.HOFFMAN-LA ROCHE AG (CH) | 2002-07-11 | — | — | WO | disclosed |
| EP-0061673-A1 | Isoquinolinesulfonyl derivatives and process for the preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069230-A1 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | ADRB1, ADRB2, ADRA2B | PRKD3 1432/4885PRKCG 1785/4885PRKCB 1131/4885 |
| US-20050107365-A1 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | ADRB1, ADRB2, ADRA2B | PRKD3 1412/4885PRKCG 1628/4885PRKCB 1007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.