Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 13/20 | 0.67 |
| ▸ | SLC6A3 known ✓ | Q01959 | 13/20 | 0.67 |
| ▸ | SLC6A2 known ✓ | P23975 | 12/20 | 0.67 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.41 |
| ▸ | DPP4 known ✓ | P27487 | 2/20 | 0.40 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.40 |
| ▸ | REN known ✓ | P00797 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL587844 | 1.00 | SLC6A4 (0.67) | SLC6A4SLC6A3SLC6A2CYP2D6CA1 | |
| Fumaric Acid SCHEMBL587845 | 1.00 | SLC6A4 (0.67) | SLC6A4SLC6A3SLC6A2CYP2D6CA1 | |
| SCHEMBL588544 | 0.91 | SLC6A4 (0.81) | SLC6A4SLC6A3SLC6A2CYP2D6CA1 | |
| SCHEMBL588656 | 0.91 | SLC6A4 (0.81) | SLC6A4SLC6A3SLC6A2CYP2D6CA1 | |
| Hydrochloric Acid SCHEMBL588156 | 0.89 | SLC6A4 (0.79) | SLC6A4SLC6A3SLC6A2CYP2D6ADRB1 | |
| Hydrochloric Acid SCHEMBL588157 | 0.89 | SLC6A4 (0.79) | SLC6A4SLC6A3SLC6A2CYP2D6ADRB1 | |
| SCHEMBL4649492 | 0.85 | SLC6A4 (0.81) | SLC6A4SLC6A3SLC6A2CYP2D6ADRB1 | |
| SCHEMBL2951055 | 0.81 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2CYP2D6CA1 | |
| SCHEMBL28761762 | 0.78 | SLC6A4 (0.60) | SLC6A4SLC6A3SLC6A2CYP2D6ADRB1 | |
| SCHEMBL5543652 | 0.78 | SLC6A4 (0.81) | SLC6A4SLC6A3SLC6A2CYP2D6CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963296-B1 | OPTICALLY ACTIVE CARBAMATES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS PHARMACEUTICAL INTERMEDIATES | EGIS GYOGYSZERGYAR NYILVANOSAN MUKOEDOE RESZVENYTARSASAG (HU) | 2012-02-15 | — | — | EP | disclosed |
| US-7851627-B2 | Optically active carbamates, process for preparation thereof and use thereof as pharmaceutical intermediates | EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (HU) | 2010-12-14 | — | — | US | disclosed |
| US-20090221823-A1 | OPTICALLY ACTIVE CARBAMATES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS PHARMACEUTICAL INTERMEDIATES | EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG (HU) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221823-A1 | OPTICALLY ACTIVE CARBAMATES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS PHARMACEUTICAL INTERMEDIATES | HRH4, HRH1, HRH2 | SLC6A4 1026/4885SLC6A3 3333/4885SLC6A2 3254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.