Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5730537 | 0.86 | KDM1A (0.42) | KDM1ARCOR1DAOTSHRL3MBTL1 | |
| SCHEMBL17554479 | 0.79 | KDM1A (0.64) | KDM1ARCOR1DAOTSHRL3MBTL1 | |
| SCHEMBL2331226 | 0.72 | KDM1A (0.47) | KDM1ARCOR1TSHRL3MBTL1LMNA | |
| SCHEMBL28833751 | 0.71 | L3MBTL1 (0.43) | KDM1ARCOR1TSHRL3MBTL1LMNA | |
| SCHEMBL28535946 | 0.70 | KDM1A (0.39) | KDM1ARCOR1DAOTSHRL3MBTL1 | |
| SCHEMBL28538325 | 0.70 | NOTUM (0.41) | KDM1ARCOR1TSHRL3MBTL1LMNA | |
| SCHEMBL19610319 | 0.70 | KDM1A (0.58) | KDM1ARCOR1TSHRL3MBTL1LMNA | |
| SCHEMBL28551725 | 0.69 | TSHR (0.47) | KDM1ARCOR1TSHRL3MBTL1LMNA | |
| SCHEMBL28783733 | 0.69 | KDM1A (0.41) | KDM1ARCOR1TSHRL3MBTL1LMNA | |
| SCHEMBL14948821 | 0.69 | KDM1A (0.38) | KDM1ARCOR1TSHRLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992101-B2 | N-(indole-2-carbonyl) and H-thieno[2,3-b]pyrrole-5-carboxamide anti-diabetic agents | PFIZER, INC. (US) | 2006-01-31 | — | — | US | disclosed |
| EP-1562899-A2 | N-(INDOLE-2-CARBONYL)AMIDES AS ANTI-DIABETIC AGENTS | Pfizer Products Inc. (US) | 2005-08-17 | — | — | EP | disclosed |
| US-20040157907-A1 | Anti-diabetic agents | PFIZER INC | 2004-08-12 | — | — | US | disclosed |
| WO-2004041780-A2 | N-(INDOLE-2-CARBONYL) AMIDES AS ANTI-DIABETIC AGENTS | PFIZER PRODUCTS INC. (US) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157907-A1 | Anti-diabetic agents | GPR119, INSR, IRS1 | KDM1A 3600/4885RCOR1 818/4885DAO 2573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.