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Sugi Predict / Compounds / Tyrosine

Tyrosine

Tyrosine

SCHEMBL9111097

CC(C)C[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.C[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ THRB P10828 1/20 0.41
▸ SLC7A5 Q01650 1/20 0.40
▸ NTSR2 O95665 4/20 0.38
▸ NTSR1 P30989 4/20 0.38
▸ NPY4R P50391 4/20 0.37
▸ NPY1R P25929 3/20 0.37
▸ NPY2R P49146 3/20 0.37
▸ SORT1 Q99523 3/20 0.37
▸ ITGB3 P05106 1/20 0.36
▸ ITGA2B P08514 1/20 0.36
▸ KISS1R Q969F8 2/20 0.35
▸ LNPEP Q9UIQ6 2/20 0.34
▸ ERAP2 Q6P179 1/20 0.34
▸ NPY5R Q15761 2/20 0.34
▸ GSR P00390 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyrosine SCHEMBL9111486 0.95 THRB (0.37) THRBSLC7A5NTSR2NTSR1NPY4R
Tyrosine SCHEMBL5886691 0.86 SLC7A5 (0.48) THRBSLC7A5ITGB3ITGA2BLNPEP
Tyrosine SCHEMBL2585997 0.85 SLC7A5 (0.56) THRBSLC7A5NTSR2NTSR1ITGB3
Tyrosine SCHEMBL4610453 0.85 SLC7A5 (0.56) THRBSLC7A5ITGB3ITGA2BLNPEP
Tyrosine SCHEMBL5358316 0.85 SLC7A5 (0.56) THRBSLC7A5ITGB3ITGA2BLNPEP
Tyrosine SCHEMBL6141122 0.83 THRB (0.43) THRBSLC7A5NTSR2NTSR1NPY4R
Tyrosine SCHEMBL1931272 0.83 THRB (0.43) THRBSLC7A5NTSR2NTSR1NPY4R
Tyrosine SCHEMBL28159330 0.83 SLC7A5 (0.58) THRBSLC7A5ITGB3ITGA2BLNPEP
Tyrosine SCHEMBL29157665 0.83 THRB (0.40) THRBSLC7A5ITGB3ITGA2BKISS1R
Tyrosine SCHEMBL9357307 0.82 THRB (0.40) THRBSLC7A5ITGB3ITGA2BKISS1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995009870-A1 CHARACTERIZATION OF MYCOPLASMA HYOPNEUMONIAE ADHESINS IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 1995-04-13 — — WO disclosed