Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887678 | 0.80 | HSD17B1 (0.35) | ENPP1ARKDM4EALDH1A1HPGD | |
| SCHEMBL5887681 | 0.77 | IDO1 (0.37) | — | |
| SCHEMBL5887363 | 0.72 | KDM4E (0.35) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL5887562 | 0.70 | GPR84 (0.36) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL4807799 | 0.68 | TDP1 (0.35) | HPGDTDP1 | |
| SCHEMBL6047631 | 0.67 | IDO1 (0.40) | KDM4EALDH1A1HPGD | |
| SCHEMBL6047603 | 0.66 | — | — | |
| SCHEMBL6047581 | 0.65 | ACHE (0.50) | ALDH1A1HPGDKMT2ANPSR1 | |
| SCHEMBL10501744 | 0.65 | HSD11B1 (0.37) | ARALDH1A1HPGDHSD11B1MEN1 | |
| SCHEMBL13345808 | 0.63 | ENPP1 (0.43) | ENPP1AKR1C3AKR1C2PDK2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037931-B2 | Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-02 | — | — | US | claimed |