Sugi Predict

Sugi Predict / Compounds / SCHEMBL5887148

SCHEMBL5887148

SCHEMBL5887148

CC[Si](CC)(CC)O[C@H]1C(=O)N(C(=O)OC(C)(C)C)[C@H]1c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 1/20 0.46
▸ KLK7 P49862 6/20 0.41
▸ RIPK1 Q13546 4/20 0.41
▸ ABCB1 P08183 1/20 0.40
▸ KLK5 Q9Y337 5/20 0.39
▸ PRSS1 P07477 2/20 0.37
▸ PRSS2 P07478 2/20 0.37
▸ PRSS3 P35030 2/20 0.37
▸ RORC P51449 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.34
▸ GAA P10253 1/20 0.34
▸ GPR119 Q8TDV5 1/20 0.34
▸ RECQL P46063 1/20 0.34
▸ STS P08842 1/20 0.34
▸ NR1H2 P55055 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5887150 1.00 ELANE (0.46) ELANEKLK7RIPK1ABCB1KLK5
SCHEMBL5745497 1.00 ELANE (0.46) ELANEKLK7RIPK1ABCB1KLK5
SCHEMBL6333635 1.00 ELANE (0.46) ELANEKLK7RIPK1ABCB1KLK5
SCHEMBL15398080 0.93 ELANE (0.43) ELANEKLK7RIPK1ABCB1KLK5
SCHEMBL6853154 0.89 ELANE (0.37) ELANEKLK7RIPK1KLK5KDM4E
SCHEMBL6853156 0.89 ELANE (0.37) ELANEKLK7RIPK1KLK5KDM4E
SCHEMBL6853151 0.89 ELANE (0.37) ELANEKLK7RIPK1KLK5KDM4E
SCHEMBL6859829 0.88 TSHR (0.42) RIPK1KDM4EGAAGPR119
SCHEMBL6859826 0.88 TSHR (0.42) RIPK1KDM4EGAAGPR119
SCHEMBL6859824 0.88 TSHR (0.42) RIPK1KDM4EGAAGPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 142 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8791279-B2 Process for preparing taxoids from baccatin derivatives using lewis acid catalyst YUNG SHIN PHARM. IND. CO., LTD. (TW) 2014-07-29 — — US claimed
US-20120149925-A1 PROCESS FOR PREPARING TAXOIDS FROM BACCATIN DERIVATIVES USING LEWIS ACID CATALYST YUNG SHIN PHARM. IND. CO., LTD. (TW) 2012-06-14 — — US claimed
US-11813241-B2 Multi-arm polymeric prodrug conjugates of taxane-based compounds NEKTAR THERAPEUTICS (US) 2023-11-14 — — US disclosed
EP-2884963-B1 STABLE PHARMACEUTICAL FORMULATION OF CABAZITAXEL YUNG SHIN PHARM IND CO LTD (TW) 2017-12-27 — — EP disclosed
US-20160340327-A1 PROCESS FOR PREPARING AMORPHOUS CABAZITAXEL SHILPA MEDICARE LIMITED (IN) 2016-11-24 — — US disclosed
US-20160340327-A1 PROCESS FOR PREPARING AMORPHOUS CABAZITAXEL SHILPA MEDICARE LIMITED (IN) 2016-11-24 — — US disclosed
US-20160235705-A1 MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF TAXANE-BASED COMPOUNDS NEKTAR THERAPEUTICS 2016-08-18 — — US disclosed
US-20160235705-A1 MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF TAXANE-BASED COMPOUNDS NEKTAR THERAPEUTICS 2016-08-18 — — US disclosed
US-9198969-B2 Stable pharmaceutical formulation of cabazitaxel YUNG SHIN PHARM. IND. CO., LTD. (TW) 2015-12-01 — — US disclosed
US-20150315164-A1 PROCESS FOR PREPARING AMORPHOUS CABAZITAXEL SHILPA MEDICARE LIMITED (IN) 2015-11-05 — — US disclosed
US-20150315164-A1 PROCESS FOR PREPARING AMORPHOUS CABAZITAXEL SHILPA MEDICARE LIMITED (IN) 2015-11-05 — — US disclosed
EP-0577083-A1 7,8-cyclopropataxanes with antitumor action Bristol-Myers Squibb Company (US) 1994-01-05 — — EP disclosed
US-5274124-A Metal alkoxides FLORIDA STATE UNIVERSITY (US) 1993-12-28 — — US disclosed
US-5272171-A Phosphonooxy and carbonate derivatives of taxol BRISTOL-MYERS SQUIBB COMPANY (US) 1993-12-21 — — US disclosed
US-5254580-A 7,8-cyclopropataxanes BRISTOL-MYERS SQUIBB COMPANY (US) 1993-10-19 — — US disclosed
EP-0558959-A1 Phosphonooxy and carbonate derivatives of taxol Bristol-Myers Squibb Company (US) 1993-09-08 — — EP disclosed
US-5229526-A METAL ALKOXIDES FLORIDA STATE UNIVERSITY (US) 1993-07-20 — — US disclosed
WO-1993006079-A1 PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND β-LACTAMS FLORIDA STATE UNIVERSITY (US) 1993-04-01 — — WO disclosed
WO-1993006094-A1 METAL ALKOXIDES FLORIDA STATE UNIVERSITY (US) 1993-04-01 — — WO disclosed
WO-1993006093-A1 10-DESACETOXYTAXOL DERIVATIVES FLORIDA STATE UNIVERSITY (US) 1993-04-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160340327-A1 PROCESS FOR PREPARING AMORPHOUS CABAZITAXEL RCC1, CSPP1, INCENP ELANE 4278/4885KLK7 447/4885RIPK1 3218/4885
US-11813241-B2 Multi-arm polymeric prodrug conjugates of taxane-based compounds PAICS, FOLR1, FOLR2 ELANE 542/4885KLK7 988/4885RIPK1 4398/4885
US-20160235705-A1 MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF TAXANE-BASED COMPOUNDS PAICS, FOLR1, FOLR2 ELANE 542/4885KLK7 988/4885RIPK1 4398/4885
US-20120149925-A1 PROCESS FOR PREPARING TAXOIDS FROM BACCATIN DERIVATIVES USING LEWIS ACID CATALYST TBCA, CEL, LTN1 ELANE 82/4885KLK7 787/4885RIPK1 3764/4885
US-20150315164-A1 PROCESS FOR PREPARING AMORPHOUS CABAZITAXEL RCC1, CSPP1, INCENP ELANE 4278/4885KLK7 447/4885RIPK1 3218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.