Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887644 | 0.94 | NPC1 (0.45) | NPC1GFERALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL5887045 | 0.94 | SMN1; SMN2 (0.49) | NPC1GFERALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL5887110 | 0.93 | LMNA (0.46) | NPC1GFERALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5886714 | 0.92 | ALDH1A1 (0.45) | NPC1GFERALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL5886766 | 0.91 | NPC1 (0.45) | NPC1GFERALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL5886765 | 0.91 | MAPT (0.48) | NPC1GFERALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL5886825 | 0.91 | NPC1 (0.45) | NPC1GFERALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL5886820 | 0.90 | SMN1; SMN2 (0.44) | NPC1GFERALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL5887375 | 0.90 | NPC1 (0.44) | NPC1GFERALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL5886747 | 0.89 | SMN1; SMN2 (0.42) | ALDH1A1SMN1; SMN2MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7019002-B2 | Substituted on 8th position with benzoic acid, ester or amide groups; anticancer agents | PHARMACIA & UPJOHN, S.P.A. (IT) | 2006-03-28 | — | — | US | claimed |
| US-20040009993-A1 | Pyridopyrimidinones derivatives as telomerase inhibitors | PHARMACIA ITALIA S.P.A. | 2004-01-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009993-A1 | Pyridopyrimidinones derivatives as telomerase inhibitors | TERT, TERF2, TERF2IP | NPC1 4067/4885GFER 4505/4885ALDH1A1 1860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.