Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887750 | 0.89 | MAPK10 (0.38) | GSK3BHSP90AA1HSP90AB1HTR1AHTR7 | |
| SCHEMBL6047660 | 0.84 | ALDH1A1 (0.40) | GSK3BALOX5HTR1AMAPTSMN1; SMN2 | |
| SCHEMBL5887288 | 0.82 | ALDH1A3 (0.41) | GSK3BNFE2L2MAOBSMN1; SMN2 | |
| SCHEMBL5887285 | 0.79 | ALKBH3 (0.44) | MAOBMAPTSMN1; SMN2 | |
| SCHEMBL6047606 | 0.76 | NR1I3 (0.39) | MAOBHTR7MAPTSMN1; SMN2 | |
| SCHEMBL7579760 | 0.75 | CASR (0.58) | CASRCASP3SENP8SENP7SENP6 | |
| SCHEMBL5887625 | 0.74 | HSP90AA1 (0.36) | CASP3SENP8SENP7SENP6HSP90AA1 | |
| SCHEMBL5887426 | 0.73 | MEN1 (0.34) | HSP90AA1HSP90AB1SMN1; SMN2 | |
| SCHEMBL5887155 | 0.72 | NOTUM (0.36) | GSK3BALOX5MAPTSMN1; SMN2 | |
| SCHEMBL5887105 | 0.70 | ESR2 (0.35) | GSK3BALOX5MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037931-B2 | Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-02 | — | — | US | claimed |
| JP-2006501194-A | — | — | 2006-01-12 | — | — | JP | claimed |
| EP-1525190-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-04-27 | — | — | EP | claimed |
| WO-2004007463-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-01-22 | — | — | WO | claimed |