SCHEMBL5887750

SCHEMBL5887750

COC1=CC[CH]C(c2cccc(Cl)c2)=C1c1ccccc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK10 P53779 3/20 0.38
MAPK14 Q16539 2/20 0.38
MAPK9 P45984 1/20 0.38
HTR7 P34969 2/20 0.35
NOTUM Q6P988 1/20 0.34
NR1I3 Q14994 1/20 0.34
STK10 O94804 1/20 0.33
GSK3B P49841 1/20 0.33
SLK Q9H2G2 1/20 0.33
MAPT P10636 1/20 0.33
CHRM1 P11229 1/20 0.33
CHRM3 P20309 1/20 0.33
HSP90AA1 P07900 1/20 0.33
HSP90AB1 P08238 1/20 0.33
CYP2A6 P11509 1/20 0.33
RORC P51449 1/20 0.32
RORB Q92753 1/20 0.32
HTR1A P08908 1/20 0.32
JAK2 O60674 1/20 0.32
JAK1 P23458 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5887303 0.89 CASR (0.39) HTR7GSK3BMAPTHSP90AA1HSP90AB1
SCHEMBL6047606 0.87 NR1I3 (0.39) MAPK10MAPK14MAPK9HTR7NOTUM
SCHEMBL5887155 0.83 NOTUM (0.36) MAPK10MAPK14MAPK9NOTUMNR1I3
SCHEMBL5887105 0.81 ESR2 (0.35) MAPK10NOTUMNR1I3GSK3BMAPT
SCHEMBL5887625 0.78 HSP90AA1 (0.36) HTR7MAPTHSP90AA1HSP90AB1CYP2A6
SCHEMBL5887426 0.74 MEN1 (0.34) HSP90AA1HSP90AB1CYP2A6
SCHEMBL5887288 0.73 ALDH1A3 (0.41) MAPK14STK10GSK3BSLK
SCHEMBL5887199 0.73 KMT2A (0.35) MAPK10
SCHEMBL6047660 0.72 ALDH1A1 (0.40) NR1I3GSK3BMAPTCYP2A6HTR1A
SCHEMBL5887667 0.72 NPC1 (0.39) HTR7MAPTHSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7037931-B2 Corticotropin releasing factor moderator; analgesics; drug abruse, drug dependency; schizophrenia JANSSEN PHARMACEUTICA N.V. (BE) 2006-05-02 US claimed
JP-2006501194-A 2006-01-12 JP claimed
EP-1525190-A1 CCK-1 RECEPTOR MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2005-04-27 EP claimed
WO-2004007463-A1 CCK-1 RECEPTOR MODULATORS JANSSEN PHARMACEUTICA, N.V. (BE) 2004-01-22 WO claimed