Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | IDH1 | O75874 | 2/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL588787 | 1.00 | ALDH1A1 (0.40) | ALDH1A1KDM4EB3GNT2S1PR4S1PR3 | |
| SCHEMBL22587371 | 0.84 | ESR1 (0.42) | — | |
| SCHEMBL22587369 | 0.84 | ESR1 (0.42) | — | |
| SCHEMBL588484 | 0.82 | APLNR (0.43) | MAPK1 | |
| SCHEMBL588486 | 0.82 | APLNR (0.43) | MAPK1 | |
| SCHEMBL347642 | 0.82 | APLNR (0.43) | MAPK1 | |
| SCHEMBL589586 | 0.78 | KDM4E (0.40) | KDM4ES1PR3S1PR1KMT2ASMN1; SMN2 | |
| SCHEMBL589588 | 0.78 | KDM4E (0.40) | KDM4ES1PR3S1PR1KMT2ASMN1; SMN2 | |
| SCHEMBL18040159 | 0.77 | CHRNA1 (0.33) | — | |
| SCHEMBL18040161 | 0.77 | CHRNA1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220267309-A1 | DIMERIC OR POLYMERIC FORM OF MUTANT IDH INHIBITOR | Epitas Biosciences (shanghai) Co., Ltd. (CN) | 2022-08-25 | — | — | US | disclosed |
| EP-3964508-A1 | DIMERIC OR POLYMERIC FORM OF MUTANT IDH INHIBITOR | Epitas Biosciences (Shanghai) Co., Ltd. (CN) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020216071-A1 | DIMERIC OR POLYMERIC FORM OF MUTANT IDH INHIBITOR | 上海仕谱生物科技有限公司 | 2020-10-29 | — | — | WO | disclosed |
| US-9434719-B2 | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH | NOVARTIS AG (CH) | 2016-09-06 | — | — | US | disclosed |
| US-9340564-B2 | Phenicol antibacterials | ZOETIS SERVICES LLC (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150266910-A1 | PHENICOL ANTIBACTERIALS | ZOETIS SERVICES LLC (US) | 2015-09-24 | — | — | US | disclosed |
| US-8114989-B2 | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2012-02-14 | — | — | US | disclosed |
| US-20100210648-A1 | PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | ASTRAZENECA R&D (SE) | 2010-08-19 | — | — | US | disclosed |
| US-20080287437-A1 | Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors | ASTRAZENECA AB (SE) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287437-A1 | Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors | ABL1, FLT3, ERBB2 | ALDH1A1 1326/4885KDM4E 1663/4885B3GNT2 2760/4885 |
| US-20220267309-A1 | DIMERIC OR POLYMERIC FORM OF MUTANT IDH INHIBITOR | IDH3B, IDH1, IDH3A | ALDH1A1 998/4885KDM4E 1050/4885B3GNT2 3844/4885 |
| US-20100210648-A1 | PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS | ABL1, FLT3, ERBB2 | ALDH1A1 1326/4885KDM4E 1663/4885B3GNT2 2760/4885 |
| US-20150266910-A1 | PHENICOL ANTIBACTERIALS | MRPL21, TTL, CTSL | ALDH1A1 3505/4885KDM4E 583/4885B3GNT2 1812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.