Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HLCS | P50747 | 6/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | IDE | P14735 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | CA12 | O43570 | 6/20 | 0.46 |
| ▸ | CA1 | P00915 | 6/20 | 0.46 |
| ▸ | CA2 | P00918 | 6/20 | 0.46 |
| ▸ | CA9 | Q16790 | 6/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599925 | 1.00 | HLCS (0.68) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL14613464 | 1.00 | HLCS (0.68) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL17641197 | 1.00 | HLCS (0.68) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL14016216 | 1.00 | HLCS (0.68) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL16841483 | 1.00 | HLCS (0.68) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL23476650 | 1.00 | HLCS (0.68) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL21515957 | 1.00 | HLCS (0.68) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL22769187 | 1.00 | HLCS (0.68) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL21553555 | 1.00 | HLCS (0.68) | HLCSTDP1MEN1ABL1LMNA | |
| SCHEMBL771650 | 1.00 | HLCS (0.68) | HLCSTDP1MEN1ABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 308 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230142803-A1 | NATURAL KILLER CELLS AND ILC3 CELLS AND USES THEREOF | CELULARITY INC. (US) | 2023-05-11 | — | — | US | claimed |
| US-20200330516-A1 | NATURAL KILLER CELLS AND USES THEREOF | CELULARITY INC. (US) | 2020-10-22 | — | — | US | claimed |
| US-10647718-B2 | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | Universitéde Montréal (CA) | 2020-05-12 | — | — | US | claimed |
| EP-3134409-B1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | UNIV MONTREAL (CA) | 2020-02-12 | — | — | EP | claimed |
| US-10336747-B2 | Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells | Université de Montréal | 2019-07-02 | — | — | US | claimed |
| EP-2807165-B1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | UNIV MONTREAL (CA) | 2019-05-15 | — | — | EP | claimed |
| US-20180346877-A1 | NATURAL KILLER CELLS AND ILC3 CELLS AND USES THEREOF | Celularity, Inc. (US) | 2018-12-06 | — | — | US | claimed |
| US-20180008637-A1 | NATURAL KILLER CELLS AND USES THEREOF | ANTHROGENESIS CORPORATION (US) | 2018-01-11 | — | — | US | claimed |
| US-20170334904-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | Université de Montréal (CA) | 2017-11-23 | — | — | US | claimed |
| US-9757378-B2 | Methods to modulate acute myeloid leukemia stem/progenitor cell expansion and/or differentiation | UNIVERSITE DE MONTREAL (CA) | 2017-09-12 | — | — | US | claimed |
| EP-3134409-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | Université de Montréal (CA) | 2017-03-01 | — | — | EP | claimed |
| US-20170037047-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | UNIVERSITE DE MONTREAL (CA) | 2017-02-09 | — | — | US | claimed |
| US-9409906-B2 | Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells | UNIVERSITE DE MONTREAL (CA) | 2016-08-09 | — | — | US | claimed |
| US-20160222017-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | Université de Montréal (CA) | 2016-08-04 | — | — | US | claimed |
| US-9296744-B2 | — | — | 2016-03-29 | — | — | US | claimed |
| WO-2015161373-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | Université de Montréal (CA) | 2015-10-29 | — | — | WO | claimed |
| US-20150011543-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | UNIVERSITE DE MONTREAL (CA) | 2015-01-08 | — | — | US | claimed |
| EP-2807165-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | Université de Montréal (CA) | 2014-12-03 | — | — | EP | claimed |
| US-20140343051-A1 | METHODS TO MODULATE ACUTE MYELOID LEUKEMIA STEM/PROGENITOR CELL EXPANSION AND/OR DIFFERENTIATION | HOPITAL MAISONNEUVE-ROSEMONT (CA) | 2014-11-20 | — | — | US | claimed |
| WO-2013110198-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | Université de Montréal (CA) | 2013-08-01 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647718-B2 | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | HPGDS, HCLS1, THPO | HLCS 642/4885TDP1 1383/4885MEN1 562/4885 |
| US-20180008637-A1 | NATURAL KILLER CELLS AND USES THEREOF | PBK, CCR3, ZFP3 | HLCS 630/4885TDP1 4607/4885MEN1 2055/4885 |
| US-20170037047-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | HPGDS, HCLS1, THPO | HLCS 642/4885TDP1 1383/4885MEN1 562/4885 |
| US-20140343051-A1 | METHODS TO MODULATE ACUTE MYELOID LEUKEMIA STEM/PROGENITOR CELL EXPANSION AND/OR DIFFERENTIATION | MCL1, AHR, MYADM | HLCS 1055/4885TDP1 4227/4885MEN1 4382/4885 |
| US-20160222017-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | IDO1, IDO2, INMT | HLCS 549/4885TDP1 2505/4885MEN1 3036/4885 |
| US-10336747-B2 | Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells | IDO1, IDO2, INMT | HLCS 549/4885TDP1 2505/4885MEN1 3036/4885 |
| US-20180346877-A1 | NATURAL KILLER CELLS AND ILC3 CELLS AND USES THEREOF | PBK, ILF3, IL2 | HLCS 372/4885TDP1 4765/4885MEN1 1575/4885 |
| US-20200330516-A1 | NATURAL KILLER CELLS AND USES THEREOF | PBK, KLKB1, KLK13 | HLCS 1414/4885TDP1 4367/4885MEN1 1190/4885 |
| US-20170334904-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | IDO1, IDO2, INMT | HLCS 549/4885TDP1 2505/4885MEN1 3036/4885 |
| US-20230142803-A1 | NATURAL KILLER CELLS AND ILC3 CELLS AND USES THEREOF | PBK, ILF3, IL2 | HLCS 372/4885TDP1 4765/4885MEN1 1575/4885 |
| US-20150011543-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | IDO1, IDO2, INMT | HLCS 549/4885TDP1 2505/4885MEN1 3036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.