Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 5/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA9 | Q16790 | 5/20 | 0.40 |
| ▸ | STK17B | O94768 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28330006 | 0.73 | SIRT6 (0.39) | SIRT6MEN1KMT2A | |
| SCHEMBL589543 | 0.73 | SIRT6 (0.37) | CA12CA1CA2CA9SIRT6 | |
| SCHEMBL17532685 | 0.72 | CKS1B (0.53) | CKS1BSKP1SKP2TDP1ALDH1A1 | |
| SCHEMBL24340866 | 0.70 | CKS1B (0.43) | CKS1BSKP1SKP2CA12CA1 | |
| SCHEMBL24455201 | 0.70 | CKS1B (0.48) | CKS1BSKP1SKP2CA12CA1 | |
| SCHEMBL5311882 | 0.70 | TDP1 (0.51) | CKS1BSKP1SKP2CA12CA1 | |
| SCHEMBL13055403 | 0.70 | CA14 (0.54) | CKS1BSKP1SKP2CA12CA1 | |
| SCHEMBL17532669 | 0.70 | TDP1 (0.51) | CKS1BSKP1SKP2CA12CA1 | |
| SCHEMBL17532689 | 0.69 | HPGD (0.46) | CKS1BSKP1SKP2CA12CA1 | |
| SCHEMBL13055399 | 0.69 | CA14 (0.53) | CKS1BSKP1SKP2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120100078-A1 | Pyrazine Derivatives and Uses Thereof in Renal Monitoring | MALLINCKRODT LLC (US) | 2012-04-26 | — | — | US | disclosed |
| US-8115000-B2 | Pyrazine derivatives and uses thereof in renal monitoring | MALLINCKRODT LLC (US) | 2012-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120100078-A1 | Pyrazine Derivatives and Uses Thereof in Renal Monitoring | CYP3A5, GLS, XDH | CKS1B 3327/4885SKP1 535/4885SKP2 1424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.