Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PTPRB | P23467 | 2/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12155009 | 0.89 | ALDH1A1 (0.71) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL12155012 | 0.89 | ALDH1A1 (0.71) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL11124323 | 0.88 | ALDH1A1 (0.78) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL6782409 | 0.87 | ALDH1A1 (0.76) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL9556731 | 0.87 | ALDH1A1 (0.76) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL12155022 | 0.87 | ALDH1A1 (0.67) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL12155029 | 0.87 | ALDH1A1 (0.67) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL11321380 | 0.87 | ALDH1A1 (0.67) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL8495876 | 0.86 | ALDH1A1 (0.74) | ALDH1A1RECQLPKMKDM4ETHRB | |
| SCHEMBL27631086 | 0.86 | ALDH1A1 (0.74) | ALDH1A1RECQLPKMKDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665744-B1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIV ROCHESTER (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8986953-B2 | Macrocyclic compounds with a hybrid peptidic/non-peptidic backbone and methods for their preparation | UNIVERSITY OF ROCHESTER (US) | 2015-03-24 | — | — | US | disclosed |
| US-20130330773-A1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | NATIONAL SCIENCE FOUNDATION | 2013-12-12 | — | — | US | disclosed |
| EP-2665744-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012100176-A2 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | UNIVERSITY OF ROCHESTER (US) | 2012-07-26 | — | — | WO | disclosed |
| US-8114629-B2 | Site specific incorporation of keto amino acids into proteins | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-02-14 | — | — | US | disclosed |
| US-20110318806-A1 | SITE SPECIFIC INCORPORATION OF KETO AMINO ACIDS INTO PROTEINS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-12-29 | — | — | US | disclosed |
| US-8071344-B2 | Biosynthesis; orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-12-06 | — | — | US | disclosed |
| EP-2062976-B1 | Site specific incorporation of keto amino acids into proteins | SCRIPPS RESEARCH INST (US) | 2011-09-28 | — | — | EP | disclosed |
| US-20110077385-A1 | Protein arrays | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-03-31 | — | — | US | disclosed |
| US-20050186656-A1 | Glycoprotein synthesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-08-25 | — | — | US | disclosed |
| US-20050186657-A1 | in vitro and in vivo; involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid; mimetics | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-08-25 | — | — | US | disclosed |
| US-20050181471-A1 | Glycoprotein synthesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-08-18 | — | — | US | disclosed |
| US-6927042-B2 | Glycoprotein synthesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-08-09 | — | — | US | disclosed |
| EP-1558747-A2 | GLYCOPROTEIN SYNTHESIS | The Scripps Research Institute (US) | 2005-08-03 | — | — | EP | disclosed |
| US-20040198637-A1 | Polypeptide incorporating unnatural amino acid chemically bonded to solid support by a chemical linkage | THE SCRIPPS RESEARCH INSTITUTE | 2004-10-07 | — | — | US | disclosed |
| WO-2004058946-A2 | PROTEIN ARRAYS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-07-15 | — | — | WO | disclosed |
| US-20040138106-A1 | Glycoprotein synthesis | THE SCRIPPS RESEARCH INSTITUTE | 2004-07-15 | — | — | US | disclosed |
| WO-2004035743-A2 | SITE SPECIFIC INCORPORATION OF KETO AMINO ACIDS INTO PROTEINS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-04-29 | — | — | WO | disclosed |
| WO-2004035605-A2 | GLYCOPROTEIN SYNTHESIS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050181471-A1 | Glycoprotein synthesis | UGGT1, ST6GAL1, ANPEP | ALDH1A1 1524/4885RECQL 4882/4885PKM 3390/4885 |
| US-20050186656-A1 | Glycoprotein synthesis | UGGT1, ST6GAL1, ANPEP | ALDH1A1 1524/4885RECQL 4882/4885PKM 3390/4885 |
| US-20110077385-A1 | Protein arrays | MAX, MRPL21, STUB1 | ALDH1A1 3707/4885RECQL 3962/4885PKM 2780/4885 |
| US-20040138106-A1 | Glycoprotein synthesis | UGGT1, ST6GAL1, ANPEP | ALDH1A1 1524/4885RECQL 4882/4885PKM 3390/4885 |
| US-20050186657-A1 | in vitro and in vivo; involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid; mimetics | DNPEP, ANPEP, NPEPPS | ALDH1A1 2446/4885RECQL 4872/4885PKM 2746/4885 |
| US-20130330773-A1 | MACROCYCLIC COMPOUNDS WITH A HYBRID PEPTIDIC/NON-PEPTIDIC BACKBONE AND METHODS FOR THEIR PREPARATION | MICA, VIP, NPEPPS | ALDH1A1 4832/4885RECQL 1348/4885PKM 2548/4885 |
| US-20040198637-A1 | Polypeptide incorporating unnatural amino acid chemically bonded to solid support by a chemical linkage | DNPEP, NPEPPS, ANPEP | ALDH1A1 2931/4885RECQL 4423/4885PKM 2335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.