Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 6/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5895808 | 0.88 | GPR4 (0.37) | ALOX15TSHROPRD1OPRK1NAMPT | |
| SCHEMBL5896565 | 0.87 | ALOX15 (0.35) | ALOX15TSHROPRD1OPRK1NAMPT | |
| SCHEMBL5895776 | 0.85 | TSHR (0.38) | ALOX15TSHRNAMPTACACBUSP2 | |
| Trifluoroacetic Acid SCHEMBL4791157 | 0.82 | TSHR (0.35) | ALOX15TSHROPRD1OPRK1NAMPT | |
| SCHEMBL5895582 | 0.82 | SPR (0.36) | ALOX15TSHROPRD1OPRK1HDAC1 | |
| SCHEMBL5895541 | 0.79 | TSHR (0.36) | ALOX15TSHROPRD1OPRK1NAMPT | |
| SCHEMBL5896118 | 0.78 | TSHR (0.35) | ALOX15TSHROPRD1OPRK1HDAC1 | |
| SCHEMBL5895165 | 0.77 | PIK3CD (0.39) | NAMPTACACBGPR119 | |
| SCHEMBL5895338 | 0.77 | GPR4 (0.37) | ALOX15TSHROPRD1OPRK1NAMPT | |
| SCHEMBL5895543 | 0.76 | TSHR (0.36) | ALOX15TSHROPRD1OPRK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091211-B2 | Cyclopentyl modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20050070609-A1 | Cyclopentyl modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070609-A1 | Cyclopentyl modulators of chemokine receptor activity | CCR5, CXCR1, ACKR3 | ALOX15 2537/4885TSHR 1067/4885OPRD1 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.