Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897690 | 0.92 | CYP19A1 (0.43) | MMP2NPSR1CYP19A1PTGS2ALDH1A1 | |
| SCHEMBL5897714 | 0.90 | LMNA (0.52) | NPSR1CYP19A1PTGS2GAAMAPT | |
| SCHEMBL17870939 | 0.76 | MMP2 (0.62) | MMP2NPSR1GAAMAPTLMNA | |
| SCHEMBL17870938 | 0.76 | MMP2 (0.62) | MMP2NPSR1GAAMAPTLMNA | |
| SCHEMBL14068809 | 0.67 | NPSR1 (0.61) | MMP2NPSR1GAAMAPTLMNA | |
| SCHEMBL16071258 | 0.67 | MMP2 (0.57) | MMP2NPSR1GAAMAPTLMNA | |
| SCHEMBL16071190 | 0.67 | NPSR1 (0.60) | MMP2NPSR1GAAMAPTLMNA | |
| SCHEMBL17474384 | 0.67 | NPSR1 (0.60) | MMP2NPSR1GAAMAPTLMNA | |
| SCHEMBL16056695 | 0.67 | MMP2 (0.57) | MMP2NPSR1GAAMAPTLMNA | |
| SCHEMBL4921860 | 0.67 | ABCG2 (0.55) | CYP19A1MAPTLMNAABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872830-B1 | Synthesized γ-carbolines | GEORGE MASON UNIVERSITY (US) | 2005-03-29 | — | — | US | claimed |
| US-7060830-B2 | Synthesized γ-carbolines | GEORGE MASON INTELLECTUAL PROPERTIES, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| US-20050131010-A1 | Synthesized gamma-carbolines | WYNNE JAMES H (US) | 2005-06-16 | — | — | US | disclosed |
| US-6872830-B1 | Synthesized γ-carbolines | GEORGE MASON UNIVERSITY (US) | 2005-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131010-A1 | Synthesized gamma-carbolines | SNCA, PARK7, PRNP | MMP2 3735/4885NPSR1 1223/4885CYP19A1 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.