Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897702 | 0.92 | MMP2 (0.48) | CYP19A1MMP2ALDH1A1NPSR1PTGS2 | |
| SCHEMBL5897714 | 0.88 | LMNA (0.52) | CYP19A1USP2ALDH1A1NPSR1KMT2A | |
| SCHEMBL17870939 | 0.68 | MMP2 (0.62) | MMP2ALDH1A1NPSR1KMT2A | |
| SCHEMBL17870938 | 0.68 | MMP2 (0.62) | MMP2ALDH1A1NPSR1KMT2A | |
| SCHEMBL6081489 | 0.67 | ALDH1A1 (0.73) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17970867 | 0.67 | ALDH1A1 (0.73) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4921860 | 0.66 | ABCG2 (0.55) | CYP19A1 | |
| SCHEMBL29278817 | 0.65 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20016363 | 0.63 | GAA (0.49) | USP2ALDH1A1KMT2A | |
| SCHEMBL6178093 | 0.63 | PSEN1 (0.70) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060830-B2 | Synthesized γ-carbolines | GEORGE MASON INTELLECTUAL PROPERTIES, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| US-20050131010-A1 | Synthesized gamma-carbolines | WYNNE JAMES H (US) | 2005-06-16 | — | — | US | disclosed |
| US-6872830-B1 | Synthesized γ-carbolines | GEORGE MASON UNIVERSITY (US) | 2005-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131010-A1 | Synthesized gamma-carbolines | SNCA, PARK7, PRNP | CYP19A1 128/4885PSEN1 38/4885PSEN2 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.