SCHEMBL589789

SCHEMBL589789

O=C(Nc1cc(C(=O)Cl)n(-c2ncccc2Cl)n1)OCc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 4/20 0.45
SMN1; SMN2 Q16637 1/20 0.43
POLB P06746 2/20 0.42
MAPT P10636 2/20 0.41
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
HTT P42858 1/20 0.41
KMT2A Q03164 1/20 0.41
PPIA P62937 1/20 0.39
P2RX7 Q99572 1/20 0.39
MGLL Q99685 1/20 0.38
SCD O00767 1/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38
TP53 P04637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL589478 0.93 PTGER1 (0.46) PTGER1SMN1; SMN2POLBMAPTMEN1
SCHEMBL592168 0.89 PTGER1 (0.43) PTGER1SMN1; SMN2POLBMAPTMEN1
SCHEMBL4261198 0.82 PTGER1 (0.42) PTGER1SMN1; SMN2POLBMAPTMEN1
SCHEMBL24621637 0.77 POLB (0.44) SMN1; SMN2POLBMEN1ALDH1A1LMNA
SCHEMBL29558552 0.75 TRPA1 (0.38) ALDH1A1LMNAHTT
SCHEMBL14234689 0.75 TRPA1 (0.38) ALDH1A1LMNAHTT
SCHEMBL589486 0.75 POLB (0.49) POLBMAPTMEN1LMNAKMT2A
SCHEMBL423612 0.72 SLC16A3 (0.43) SMN1; SMN2POLBMAPTALDH1A1LMNA
SCHEMBL30863650 0.72 ALDH1A1 (0.45) SMN1; SMN2MAPTALDH1A1LMNAKMT2A
SCHEMBL28692403 0.72 ALDH1A1 (0.45) SMN1; SMN2MAPTALDH1A1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2093223-B1 PROCESS AND INTERMEDIATES FOR PRODUCTION OF AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA (JP) 2013-08-21 EP disclosed
US-8115006-B2 Process for producing anthranilamide compound ISHIHARA SANGYO KAISHA, LTD. (JP) 2012-02-14 US disclosed
US-20100063293-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA ,LTD. (JP) 2010-03-11 US disclosed
EP-2093223-A1 PROCESS FOR PRODUCTION OF ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2009-08-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100063293-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND NAAA, AAAS, AADAC PTGER1 4293/4885SMN1; SMN2 4856/4885POLB 622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.