SCHEMBL589486

SCHEMBL589486

O=C(OCc1ccccc1)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.49
JMJD6 Q6NYC1 1/20 0.42
L3MBTL1 Q9Y468 4/20 0.41
CASP3 P42574 2/20 0.41
SENP8 Q96LD8 2/20 0.41
SENP7 Q9BQF6 2/20 0.41
SENP6 Q9GZR1 2/20 0.41
TSHR P16473 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 3/20 0.41
MEN1 O00255 1/20 0.41
TDP1 Q9NUW8 3/20 0.40
LMNA P02545 1/20 0.40
EGLN1 Q9GZT9 1/20 0.40
MAPT P10636 1/20 0.39
DHODH Q02127 2/20 0.38
SLC6A2 P23975 1/20 0.38
SLC6A3 Q01959 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL589650 0.89 KMT2A (0.46) POLBL3MBTL1CASP3SENP8SENP7
SCHEMBL1762554 0.85 ALDH1A1 (0.47) POLBJMJD6L3MBTL1RAB9ATDP1
SCHEMBL29372796 0.85 ALDH1A1 (0.47) POLBJMJD6L3MBTL1RAB9ATDP1
SCHEMBL591320 0.83 TRPA1 (0.41) NPSR1RAB9AMAPTDHODH
SCHEMBL28801877 0.83 DHODH (0.39) DHODH
SCHEMBL15289958 0.83 DHODH (0.42) DHODH
SCHEMBL28278736 0.83 CYP3A4 (0.37) CASP3SENP8SENP7SENP6TSHR
SCHEMBL23249321 0.82 DHODH (0.45) POLBTSHRDHODH
SCHEMBL29504162 0.82 DHODH (0.45) POLBTSHRDHODH
SCHEMBL535475 0.81 DHODH (0.41) LMNADHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2093223-B1 PROCESS AND INTERMEDIATES FOR PRODUCTION OF AN ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA (JP) 2013-08-21 EP disclosed
CN-101558056-B Process for producing anthranilamide compound ISHIHARA SANGYO KAISHA 2013-05-01 CN disclosed
US-8115006-B2 Process for producing anthranilamide compound ISHIHARA SANGYO KAISHA, LTD. (JP) 2012-02-14 US disclosed
US-20100063293-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA ,LTD. (JP) 2010-03-11 US disclosed
EP-2093223-A1 PROCESS FOR PRODUCTION OF ANTHRANILAMIDE COMPOUND ISHIHARA SANGYO KAISHA, LTD. (JP) 2009-08-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100063293-A1 PROCESS FOR PRODUCING ANTHRANILAMIDE COMPOUND NAAA, AAAS, AADAC POLB 622/4885JMJD6 2341/4885L3MBTL1 2700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.