Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17539122 | 1.00 | MAPT (0.45) | MAPTHTTMEN1THRBKMT2A | |
| SCHEMBL10972888 | 1.00 | MAPT (0.45) | MAPTHTTMEN1THRBKMT2A | |
| SCHEMBL14480533 | 0.95 | HTT (0.50) | MAPTHTTMEN1THRBKMT2A | |
| SCHEMBL14480434 | 0.95 | HTT (0.50) | MAPTHTTMEN1THRBKMT2A | |
| SCHEMBL14480388 | 0.95 | HTT (0.50) | MAPTHTTMEN1THRBKMT2A | |
| SCHEMBL14480438 | 0.95 | HTT (0.50) | MAPTHTTMEN1THRBKMT2A | |
| SCHEMBL23567226 | 0.91 | MAPT (0.38) | MAPTHTTMEN1THRBKMT2A | |
| SCHEMBL23567305 | 0.91 | MAPT (0.38) | MAPTHTTMEN1THRBKMT2A | |
| SCHEMBL23567303 | 0.91 | MAPT (0.38) | MAPTHTTMEN1THRBKMT2A | |
| SCHEMBL23567297 | 0.91 | MAPT (0.38) | MAPTHTTMEN1THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729153-B1 | CONDENSED PYRIMIDINE NUCLEOSIDE ANALOGS AS ANTI-VIRAL AGENTS | UNIV CARDIFF (GB) | 2015-09-16 | — | — | EP | disclosed |
| US-8551966-B2 | Chemical compounds | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2013-10-08 | — | — | US | disclosed |
| US-20130012468-A1 | CHEMICAL COMPOUNDS | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2013-01-10 | — | — | US | disclosed |
| US-7019135-B2 | Anti-viral pyrimidine nucleoside analogues | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2006-03-28 | — | — | US | disclosed |
| EP-1280813-B1 | ANTI-VIRAL PYRIMIDINE NUCLEOSIDE ANALOGUES | UNIV CARDIFF (GB) | 2003-11-12 | — | — | EP | disclosed |
| US-20030176370-A1 | Anti-viral pyrimidine nucleoside analogues | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2003-09-18 | — | — | US | disclosed |
| EP-1280813-A1 | ANTI-VIRAL PYRIMIDINE NUCLEOSIDE ANALOGUES | University College Cardiff Consultants Limited (GB) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001085749-A1 | ANTI-VIRAL PYRIMIDINE NUCLEOSIDE ANALOGUES | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2001-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176370-A1 | Anti-viral pyrimidine nucleoside analogues | CCNO, TYMP, TK1 | MAPT 3872/4885HTT 1238/4885MEN1 3672/4885 |
| US-20130012468-A1 | CHEMICAL COMPOUNDS | ADAR, UMPS, RNASEL | MAPT 3571/4885HTT 3013/4885MEN1 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.