Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681237 | 0.83 | GLA (0.36) | KDM4EALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL2422131 | 0.58 | HSD17B10 (0.50) | HSD17B10KDM4EALDH1A1POLBMAPT | |
| SCHEMBL11427988 | 0.56 | HSD17B10 (0.48) | HSD17B10KDM4EALDH1A1POLBMAPT | |
| SCHEMBL9693848 | 0.56 | HSD17B10 (0.48) | HSD17B10KDM4EALDH1A1POLBMAPT | |
| SCHEMBL5945932 | 0.56 | PTGS1 (0.42) | HSD17B10KDM4EALDH1A1POLBMAPT | |
| SCHEMBL5002371 | 0.56 | SMN1; SMN2 (0.56) | HSD17B10KDM4EALDH1A1POLBMAPT | |
| SCHEMBL13104001 | 0.56 | HSD17B10 (0.43) | HSD17B10KDM4EALDH1A1POLBMAPT | |
| SCHEMBL529016 | 0.56 | HSD17B10 (0.43) | HSD17B10KDM4EALDH1A1POLBMAPT | |
| SCHEMBL515800 | 0.56 | PTGS1 (0.52) | HSD17B10KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL16050263 | 0.55 | HSD17B10 (0.42) | HSD17B10KDM4EALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399600-B1 | ANTIBIOTIC RESISTANT BATERIA INFECTIONS | SIMON FRASER UNIVERSITY (CA) | 2002-06-04 | — | — | US | claimed |
| US-20060069091-A9 | Oxazinones and methods for their use and synthesis | CHIROLOGIX PHARMACEUTICALS, INC. | 2006-03-30 | — | — | US | disclosed |
| US-20050124612-A1 | Oxazinones and methods for their use and synthesis | CHIROLOGIX PHARMACEUTICALS, INC. | 2005-06-09 | — | — | US | disclosed |
| US-6861416-B2 | Oxazinones and methods for their use and synthesis | CHIROLOGIX PHARMACEUTICALS, INC. (CA) | 2005-03-01 | — | — | US | disclosed |
| US-20040023956-A1 | New intermediates and synthetic methods for the stereospecific synthesis of oxazinone compounds, which are useful, for example, as antibiotics. The invention also pertains to novel olefinic oxazinone compounds, methods for | CHIROLOGIX PHARMACEUTICALS, INC (CA) | 2004-02-05 | — | — | US | disclosed |
| US-6660734-B1 | Oxazinones having antibacterial activity | SIMON FRASER UNIVERSITY (CA) | 2003-12-09 | — | — | US | disclosed |
| US-6399600-B1 | ANTIBIOTIC RESISTANT BATERIA INFECTIONS | SIMON FRASER UNIVERSITY (CA) | 2002-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069091-A9 | Oxazinones and methods for their use and synthesis | DHPS, COASY, SQLE | HSD17B10 48/4885KDM4E 1661/4885ALDH1A1 584/4885 |
| US-20050124612-A1 | Oxazinones and methods for their use and synthesis | DHPS, COASY, SQLE | HSD17B10 48/4885KDM4E 1661/4885ALDH1A1 584/4885 |
| US-20040023956-A1 | New intermediates and synthetic methods for the stereospecific synthesis of oxazinone compounds, which are useful, for example, as antibiotics. The invention also pertains to novel olefinic oxazinone compounds, methods for | SQLE, DHPS, COASY | HSD17B10 68/4885KDM4E 1949/4885ALDH1A1 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.