Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899593 | 0.92 | KMT2A (0.54) | ADAMTS5KMT2AMAPTTSHRHSD11B1 | |
| SCHEMBL6402817 | 0.85 | KMT2A (0.58) | KDM4EKMT2AMAPTGAALMNA | |
| SCHEMBL5899682 | 0.84 | GAA (0.50) | ALDH1A1KMT2AMAPTTSHRGAA | |
| SCHEMBL15705806 | 0.83 | POLB (0.60) | ALDH1A1KDM4EADAMTS5STAT3KMT2A | |
| SCHEMBL27628054 | 0.82 | TDP1 (0.49) | ALDH1A1STAT3KMT2AMAPTTSHR | |
| SCHEMBL5899607 | 0.81 | HSD11B1 (0.57) | ALDH1A1KDM4EUSP2KMT2AMAPT | |
| SCHEMBL5899473 | 0.81 | GAA (0.50) | KMT2AMAPTHSD11B1GAA | |
| SCHEMBL15705773 | 0.80 | MMP1 (0.54) | ALDH1A1KDM4ESTAT3KMT2AGAA | |
| SCHEMBL11603483 | 0.79 | RECQL (0.59) | ALDH1A1KDM4EKMT2AHSD11B1TAS2R14 | |
| SCHEMBL2335204 | 0.79 | GAA (0.56) | STAT3KMT2AMAPTTSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | WYETH | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | ALDH1A1 139/4885KDM4E 1333/4885USP2 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.