Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.47 |
| ▸ | HTR3B | O95264 | 4/20 | 0.47 |
| ▸ | HTR3A | P46098 | 4/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | HTR5A | P47898 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | NCF1 | P14598 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8791762 | 0.84 | KMT2A (0.46) | HTR2AHTR2CADRA2AKDM4EALDH1A1 | |
| SCHEMBL11555106 | 0.78 | HTR3E (0.53) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL2346242 | 0.74 | ADRB1 (0.60) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL2348309 | 0.73 | HTR3A (0.44) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL2342043 | 0.73 | HTR3A (0.56) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL2345082 | 0.73 | HTR3E (0.48) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL2350412 | 0.73 | HTR6 (0.63) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL2346369 | 0.73 | ADRB1 (0.53) | HTR2AHTR2CHTR3EHTR3BHTR3A | |
| SCHEMBL28741142 | 0.73 | KDM4E (0.51) | HTR2AHTR2CHTR1AKDM4ELMNA | |
| SCHEMBL2348220 | 0.72 | ADRB1 (0.62) | HTR2AHTR2CHTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256738-A1 | USE OF SELECTIVE DOPAMINE D4 RECEPTOR AGONISTS FOR TREATING SEXUAL DYSFUNCTION | ABBVIE INC. | 2014-09-11 | — | — | US | disclosed |
| US-20060276484-A1 | Use of selective dopamine D4 receptor agonists for treating sexual dysfunction | ABBVIE INC. | 2006-12-07 | — | — | US | disclosed |