Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5904305 | 0.84 | KDM1A (0.59) | HPGDSKDM4EKDM1AMAPTNPSR1 | |
| SCHEMBL5904131 | 0.77 | KDM1A (0.50) | HPGDSKDM4EKDM1AMAPTNPSR1 | |
| SCHEMBL7284716 | 0.75 | KDM4E (0.65) | HPGDSKDM4EKDM1AMAPTALDH1A1 | |
| SCHEMBL31097921 | 0.74 | CNR1 (0.48) | KDM4EKDM1AMAPTNPSR1MAPKAPK2 | |
| SCHEMBL15420633 | 0.73 | HPGDS (0.51) | HPGDSKDM4EKDM1ANPSR1ALDH1A1 | |
| SCHEMBL11751427 | 0.73 | CLK4 (0.55) | HPGDSKDM4EMAPTNPSR1ALDH1A1 | |
| SCHEMBL31651999 | 0.73 | HPGDS (0.51) | HPGDSKDM4EMAPTALDH1A1HTT | |
| SCHEMBL21597025 | 0.73 | HPGDS (0.51) | HPGDSKDM4EMAPTALDH1A1HTT | |
| SCHEMBL1162717 | 0.72 | KDM4E (0.61) | KDM4EMAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL1623590 | 0.71 | ALDH1A1 (0.56) | KDM4EMAPTNPSR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060128757-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | ASTELLAS PHARMA INC. (JP) | 2006-06-15 | — | — | US | disclosed |
| EP-1355885-A1 | PYRIDINE DERIVATIVES USEFUL AS CYCLOOXYGENASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-10-29 | — | — | EP | disclosed |
| US-20030119877-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | ASTELLAS PHARMA INC. (JP) | 2003-06-26 | — | — | US | disclosed |
| WO-2002055502-A1 | PYRIDINE DERIVATIVES USEFUL AS CYCLOOXYGENASE INHIBITOR | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030119877-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | PTGS1, PTGIS, PTGER1 | HPGDS 17/4885KDM4E 1924/4885KDM1A 408/4885 |
| US-20060128757-A1 | Pyridine derivatives useful as cyclooxygenase inhibitor | PTGS1, PTGIS, PTGS2 | HPGDS 23/4885KDM4E 1069/4885KDM1A 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.