Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trinitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 11/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | TTR | P02766 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.76 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | CA1 | P00915 | 2/20 | 0.60 |
| ▸ | CA2 | P00918 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trinitrophenol SCHEMBL8744 | 0.98 | GPR35 (0.79) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL253750 | 0.98 | GPR35 (0.79) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL7514069 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL7514072 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL223710 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL2260895 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL7161632 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL7529527 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL11029133 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL10361561 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023068288-A1 | METHOD FOR PRODUCING DIPHENYL CARBONATE | 旭化成株式会社 | 2023-04-27 | — | — | WO | disclosed |
| WO-2023058681-A1 | METHOD FOR PRODUCING HIGH-PURITY DIARYL CARBONATE | 旭化成株式会社 | 2023-04-13 | — | — | WO | disclosed |
| CN-105925325-B | Fuel additive mixture and application thereof | 四川马孚科技有限公司 | 2020-04-03 | — | — | CN | disclosed |
| CN-105950234-B | Fuel additive mixture and application thereof | 四川马孚科技有限公司 | 2020-04-03 | — | — | CN | disclosed |
| CN-106085521-B | solid ferrous picrate formula, preparation method and application | 四川马孚科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| CN-106118766-A | The Preparation method and use of solid picric acid ferrous iron formula | 成都马孚科技有限公司 | 2016-11-16 | — | — | CN | disclosed |
| CN-106085521-A | Solid picric acid ferrous iron formula, Preparation method and use | 成都马孚科技有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-106085522-A | The Preparation method and use of the solid mixture containing picric acid ferrous iron | 成都马孚科技有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-105950234-A | Fuel additive mixture and application thereof | 成都马孚科技有限公司 | 2016-09-21 | — | — | CN | disclosed |
| CN-105950235-A | Fuel additive mixture and application thereof | 成都马孚科技有限公司 | 2016-09-21 | — | — | CN | disclosed |
| CN-1164529-A | Process for preparing diaryl carbonate | UBE INDUSTRIES (JP) | 1997-11-12 | — | — | CN | disclosed |
| EP-0795539-A1 | Process for producing a diaryl carbonate | UBE INDUSTRIES LIMITED (JP) | 1997-09-17 | — | — | EP | disclosed |
| EP-0309291-B1 | Nitrogen-containing oxacalixarene and calixarene derivatives, polymers including groups related to such derivatives, polymers including groups related to such derivatives, and use of such compounds | LOCTITE IRELAND LTD (IE) | 1993-10-27 | — | — | EP | disclosed |
| EP-0237265-B1 | CALIXARENE DERIVATIVES AND USE OF SUCH COMPOUNDS FOR SEQUESTRATION OF METALS | LOCTITE (IRELAND) Ltd. (IE) | 1992-09-09 | — | — | EP | disclosed |
| US-5043415-A | Sequestration of metals | LOCTITE (IRELAND) LTD. (IE) | 1991-08-27 | — | — | US | disclosed |
| US-4882449-A | Calixarene derivatives, and use of such compounds for sequestration of metals | LOCTITE CORPORATION (US) | 1989-11-21 | — | — | US | disclosed |
| EP-0309291-A1 | Nitrogen-containing oxacalixarene and calixarene derivatives, polymers including groups related to such derivatives, polymers including groups related to such derivatives, and use of such compounds | LOCTITE (IRELAND) Ltd. (IE) | 1989-03-29 | — | — | EP | disclosed |
| EP-0237265-A2 | Calixarene derivatives and use of such compounds for sequestration of metals | LOCTITE (IRELAND) Ltd. (IE) | 1987-09-16 | — | — | EP | disclosed |
| US-4673687-A | TANNATE COMPLEX OF PICRO CUPRIC AMMONIUM FORMATE, SURFACTANT | SOURCE TECHNOLOGY BIOLOGICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |
| US-4544666-A | COMPLEXING AMMONIUM FORMATE, PICRIC ACID AND TANNIC ACID IN PRESENCE OF SURFACTANT | PHYTON/AG, INC. (US) | 1985-10-01 | — | — | US | disclosed |