Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trinitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 11/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | HPGD | P15428 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | TTR | P02766 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.76 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trinitrophenol SCHEMBL253750 | 0.98 | GPR35 (0.79) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL8744 | 0.98 | GPR35 (0.79) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL223710 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL7514072 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL10361561 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL2260895 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL7514069 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL7161632 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL11029133 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 | |
| Trinitrophenol SCHEMBL5908860 | 0.95 | GPR35 (0.76) | GPR35ALDH1A1HPGDMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8105899-A | — | — | None | — | — | JP | disclosed |
| CN-101443399-A | Stabilizer composition for halogenated polymers with improved initial color and improved color retention | BAERLOCHER GMBH (DE) | 2009-05-27 | — | — | CN | disclosed |
| CN-101248129-A | Stabilizer composition based on nitrogen compounds for stabilizing halogenated polymers | BAERLOCHER GMBH (DE) | 2008-08-20 | — | — | CN | disclosed |
| US-20020155443-A1 | Metal binding DNA interactive compounds | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2002-10-24 | — | — | US | disclosed |
| EP-0703453-B1 | Method for the determination of creatinine and urinary protein | BAYER AG (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-0703453-A1 | Dry reagent for creatinine assay | Bayer Corporation (US) | 1996-03-27 | — | — | EP | disclosed |
| US-5464777-A | Dry reagent for creatinine assay | MILES INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-4668397-A | CYCLODIMERIZATION, TETRAPEPTIDES | AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY (JP) | 1987-05-26 | — | — | US | disclosed |
| EP-0153370-A1 | A METHOD FOR PREPARATION OF A UNITARY DRY REAGENT SYSTEM CONTAINING HETEROGENEOUS CHEMICALS | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-09-04 | — | — | EP | disclosed |
| WO-1985001107-A1 | A METHOD FOR PREPARATION OF A UNITARY DRY REAGENT SYSTEM CONTAINING HETEROGENEOUS CHEMICALS | AMERICAN HOSPITAL SUPPLY CORPORATION (US) | 1985-03-14 | — | — | WO | disclosed |
| US-4147545-A | FOR DIAZO-SENSITIZED PHOTOSENSITIVE COATINGS | POLYCHROME CORPORATION (US) | 1979-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020155443-A1 | Metal binding DNA interactive compounds | DNMT1, DNMT3A, DNMT3B | GPR35 4442/4885ALDH1A1 2457/4885HPGD 3229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.