Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FASN | P49327 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5913 | 1.00 | KMT2A (0.44) | KMT2AFASNKDM1AMAPTUSP30 | |
| SCHEMBL6637 | 0.92 | KMT2A (0.52) | KMT2AFASNKDM1AMAPTUSP30 | |
| SCHEMBL6635 | 0.92 | KMT2A (0.52) | KMT2AFASNKDM1AMAPTUSP30 | |
| SCHEMBL6905 | 0.85 | KAT2B (0.43) | KMT2AMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL6123 | 0.85 | NPY5R (0.42) | FASNMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL6121 | 0.85 | NPY5R (0.42) | FASNMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL6903 | 0.85 | KAT2B (0.43) | KMT2AMAPTALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL7675 | 0.84 | FASN (0.44) | FASNKDM1AUSP30KCNH2VNN1 | |
| SCHEMBL7673 | 0.84 | FASN (0.44) | FASNKDM1AUSP30KCNH2VNN1 | |
| SCHEMBL7209 | 0.82 | STAT3 (0.45) | KMT2AMAPTALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |