Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | FASN | P49327 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 4/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6635 | 1.00 | KMT2A (0.52) | KMT2AKAT2BFASNMAPTLMNA | |
| SCHEMBL5913 | 0.92 | KMT2A (0.44) | KMT2AKAT2BFASNMAPTLMNA | |
| SCHEMBL5915 | 0.92 | KMT2A (0.44) | KMT2AKAT2BFASNMAPTLMNA | |
| SCHEMBL6261 | 0.85 | KAT2B (0.44) | KMT2AKAT2BMAPTLMNARAB9A | |
| SCHEMBL6263 | 0.85 | KAT2B (0.44) | KMT2AKAT2BMAPTLMNARAB9A | |
| SCHEMBL5906 | 0.85 | NPY5R (0.42) | KMT2AFASNMAPTHCAR3MAPK1 | |
| SCHEMBL5904 | 0.85 | NPY5R (0.42) | KMT2AFASNMAPTHCAR3MAPK1 | |
| SCHEMBL6060 | 0.84 | FASN (0.44) | FASNKDM1AUSP30KCNH2VNN1 | |
| SCHEMBL6062 | 0.84 | FASN (0.44) | FASNKDM1AUSP30KCNH2VNN1 | |
| SCHEMBL7663 | 0.82 | ALDH1A1 (0.51) | KMT2AMAPTLMNARAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |