Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275598 | 0.89 | LMNA (0.64) | LMNAMAPK1KMT2ABLMHPGD | |
| Bicarbonate SCHEMBL9248270 | 0.84 | GABRA1 (0.56) | LMNAGABRA1GABRB2KMT2AGABRB1 | |
| Hydrogen Peroxide SCHEMBL20593356 | 0.81 | GABRA1 (0.65) | LMNAGABRA1GABRB2KMT2AGABRB1 | |
| Hydrogen Peroxide SCHEMBL99126 | 0.81 | GABRA1 (0.65) | LMNAGABRA1GABRB2KMT2AGABRB1 | |
| Hydrogen Peroxide SCHEMBL30120583 | 0.81 | GABRA1 (0.65) | LMNAGABRA1GABRB2KMT2AGABRB1 | |
| Hydrogen Peroxide SCHEMBL29394264 | 0.81 | GABRA1 (0.65) | LMNAGABRA1GABRB2KMT2AGABRB1 | |
| Hydrogen Peroxide SCHEMBL35519 | 0.81 | GABRA1 (0.65) | LMNAGABRA1GABRB2KMT2AGABRB1 | |
| SCHEMBL1343676 | 0.80 | PTGS2 (0.50) | LMNAMAPK1GABRA1GABRB2KMT2A | |
| SCHEMBL28442450 | 0.80 | SRC (0.50) | LMNAGABRA1GABRB2KMT2AGABRB1 | |
| SCHEMBL168464 | 0.78 | LMNA (0.52) | LMNAMAPK1KMT2ABLMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060247280-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247280-A1 | Compounds and methods | METAP2, DNPEP, METAP1 | LMNA 4627/4885MAPK1 4089/4885GABRA1 4795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.