Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CLK1 | P49759 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | Q9HBH1 | 1/20 | 0.30 | |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3935907 | 0.99 | HPGD (0.36) | HPGDCYP2C9KDM4EDUSP3L3MBTL1 | |
| SCHEMBL13763557 | 0.79 | MAPT (0.39) | HPGDKDM4EL3MBTL1SNCAHSD17B10 | |
| SCHEMBL3935905 | 0.75 | MAPT (0.53) | HPGDCYP2C9KDM4EDUSP3L3MBTL1 | |
| SCHEMBL3935897 | 0.75 | MAPT (0.53) | HPGDCYP2C9KDM4EDUSP3L3MBTL1 | |
| Bromide SCHEMBL5918627 | 0.75 | MEN1 (0.52) | HPGDCYP2C9KDM4EDUSP3L3MBTL1 | |
| SCHEMBL3945055 | 0.74 | ALDH1A1 (0.35) | HPGDKDM4ESNCAHSD17B10MAPT | |
| SCHEMBL13763560 | 0.74 | MAPT (0.35) | HPGDKDM4EL3MBTL1HSD17B10MAPT | |
| SCHEMBL10036144 | 0.73 | MAPT (0.41) | KDM4EL3MBTL1MAPTPOLBCYP2C19 | |
| SCHEMBL13092568 | 0.71 | MAPT (0.56) | HPGDCYP2C9KDM4EDUSP3L3MBTL1 | |
| SCHEMBL5694880 | 0.71 | MAPT (0.45) | CYP2C9KDM4EL3MBTL1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060162098-A1 | Use of polycationic compounds for dyeing keratin fibres | L'OREAL S.A. (FR) | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060162098-A1 | Use of polycationic compounds for dyeing keratin fibres | KRT18, DSG1, DSP | HPGD 828/4885CYP2C9 1628/4885KDM4E 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.