Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | DHPS | P49366 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754409 | 0.81 | DPP4 (0.61) | DPP4ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL12203517 | 0.77 | ALDH1A1 (0.49) | ADORA2AADORA1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3368583 | 0.72 | DPP4 (1.00) | DPP4ADORA2AADORA1ADORA3CYP3A4 | |
| SCHEMBL3369169 | 0.70 | ADORA1 (0.71) | DPP4ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL5753689 | 0.70 | DPP4 (0.56) | DPP4ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL5744860 | 0.70 | ADORA1 (0.60) | DPP4ADORA2AADORA1ADORA2BTP53 | |
| SCHEMBL2876291 | 0.69 | CLK4 (0.56) | ADORA2AADORA1NPC1TP53NFKB1 | |
| SCHEMBL9263132 | 0.68 | ABL1 (0.59) | NPC1TP53RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL28196625 | 0.67 | CYP1A2 (0.72) | DPP4ADORA2AADORA1ADORA3TP53 | |
| SCHEMBL13336381 | 0.66 | PIN1 (0.47) | NPC1TP53RAB9ASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060229308-A1 | Substituted pyrirmidin-4-ylamine analogues as vanilloid receptor ligands | NEUROGEN CORPORATION (US) | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229308-A1 | Substituted pyrirmidin-4-ylamine analogues as vanilloid receptor ligands | TRPV1, GPR17, TRPV2 | DPP4 1375/4885ADORA2A 621/4885ADORA1 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.