Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | TK1 | P04183 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | TK2 | O00142 | 6/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL591722 | 0.91 | HPGD (0.52) | HPGDTK1ADRA1DADRA1AADRA1B | |
| SCHEMBL593377 | 0.89 | KDM4E (0.53) | HPGDTK1ADRA1DADRA1AADRA1B | |
| SCHEMBL593818 | 0.88 | TK2 (0.53) | HPGDTK1ADRA1DADRA1AADRA1B | |
| SCHEMBL591973 | 0.88 | ADRA1D (0.53) | HPGDTK1ADRA1DADRA1AADRA1B | |
| SCHEMBL592220 | 0.87 | HPGD (0.48) | HPGDADRA1DADRA1AADRA1B | |
| SCHEMBL591628 | 0.87 | MAPK1 (0.58) | HPGDTK1ADRA1DADRA1AADRA1B | |
| SCHEMBL591457 | 0.87 | HPGD (0.48) | HPGDTK1ADRA1DADRA1AADRA1B | |
| SCHEMBL593213 | 0.87 | ADRA1D (0.50) | HPGDTK1ADRA1DADRA1AADRA1B | |
| SCHEMBL593080 | 0.86 | DRD2 (0.52) | HPGDTK1ADRA1DADRA1AADRA1B | |
| SCHEMBL593078 | 0.86 | MAPK1 (0.54) | HPGDTK1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828146-B1 | SUBSTITUTED N-HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | ABBVIE DEUTSCHLAND (DE) | 2014-11-05 | — | — | EP | claimed |
| EP-1828146-B1 | SUBSTITUTED N-HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | ABBVIE DEUTSCHLAND (DE) | 2014-11-05 | — | — | EP | disclosed |
| US-8114875-B2 | Substituted N-heterocyclic compounds and their use as dopamine D3 receptor ligands | ABBOTT GMBH & CO. KG (DE) | 2012-02-14 | — | — | US | disclosed |
| US-20090054449-A1 | Substituted N-heterocyclic Compounds and Their Use as Dopamine D3 Receptor Ligands | ABBOTT GMBH & CO. KG (DE) | 2009-02-26 | — | — | US | disclosed |
| EP-1828146-A1 | SUBSTITUTED N-HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | Abbott GmbH & Co. KG (DE) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006066885-A1 | SUBSTITUTED N-HETEROCYCLIC COMPOUNDS AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | ABBOTT GMBH & CO. KG (DE) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054449-A1 | Substituted N-heterocyclic Compounds and Their Use as Dopamine D3 Receptor Ligands | SLC6A3, DRD3, HTR3A | HPGD 618/4885TK1 1596/4885ADRA1D 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.