Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ACR | P10323 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702346 | 0.85 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL4704061 | 0.78 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL5244156 | 0.75 | F2 (0.46) | SMN1; SMN2ALDH1A1NPC1RAB9ATP53 | |
| SCHEMBL4705980 | 0.74 | GPR35 (0.43) | ALDH1A1MAPK1MAPTPOLBHTT | |
| SCHEMBL4704082 | 0.67 | POLB (0.50) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL8267163 | 0.65 | SMN1; SMN2 (0.88) | SMN1; SMN2ALDH1A1USP2NPC1RAB9A | |
| SCHEMBL15653736 | 0.64 | KMT2A (0.61) | MAPK1TP53MAPTGAAPOLB | |
| SCHEMBL30314831 | 0.64 | SCD (0.43) | ALDH1A1MAPTGAAPOLB | |
| SCHEMBL10632420 | 0.64 | GRM4 (0.67) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30439916 | 0.64 | GRM4 (0.67) | SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060281778-A1 | Compounds for inhibiting KSP Kinesin activity | SCHERING CORPORATION | 2006-12-14 | — | — | US | disclosed |
| US-20060247320-A1 | Compounds for inhibiting KSP kinesin activity | SCHERING CORPORATION | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281778-A1 | Compounds for inhibiting KSP Kinesin activity | KIFC1, KIF5B, KIF2C | SMN1; SMN2 2022/4885ALDH1A1 2371/4885USP2 2868/4885 |
| US-20060247320-A1 | Compounds for inhibiting KSP kinesin activity | KIFC1, KIF5B, KIF2C | SMN1; SMN2 2022/4885ALDH1A1 2371/4885USP2 2868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.