Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 7/20 | 0.56 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.55 |
| ▸ | RXRB | P28702 | 6/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.51 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.51 |
| ▸ | RXRG | P48443 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28611584 | 0.86 | TUBB1 (0.74) | TUBB1NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL6700595 | 0.86 | PTGDR2 (0.54) | TUBB1NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL6035502 | 0.85 | TUBB1 (0.72) | TUBB1NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL6700077 | 0.83 | ERN1 (0.56) | NPC1RAB9APOLBSMN1; SMN2RXRA | |
| SCHEMBL6693981 | 0.82 | RAB9A (0.56) | TUBB1NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL29958502 | 0.81 | NR4A2 (0.56) | NPC1RAB9APOLBSMN1; SMN2RXRA | |
| SCHEMBL6700704 | 0.81 | RXRA (0.48) | TUBB1NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL7147744 | 0.81 | TUBB1 (0.66) | TUBB1NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL1987664 | 0.80 | CA12 (0.67) | RAB9AKDM4EALDH1A1 | |
| SCHEMBL29956605 | 0.80 | CA12 (0.67) | RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060142315-A1 | Substituted biaryl piperazinyl-pyridine analogues | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2006-06-29 | — | — | US | disclosed |
| WO-2004082613-A2 | 2,4-DIAMINO-5-[5’-SUBSTITUTED-BENZYL] PYRIMIDINES AND 2,4-DIAMINO-6-[5’-SUBSTITUTED-BENZYL] QUINAZOLINES | DANA FARBER CANCER INSTITUTE (US) | 2004-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142315-A1 | Substituted biaryl piperazinyl-pyridine analogues | DHFR, DPYD, DLD | TUBB1 1549/4885NPC1 1110/4885RAB9A 4201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.