Sugi Predict

Sugi Predict / Compounds / SCHEMBL5952262

SCHEMBL5952262

SCHEMBL5952262

CC(=O)Nc1ccc(OC(F)F)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 5/20 0.61
▸ KMT2A Q03164 5/20 0.61
▸ ALDH1A1 P00352 5/20 0.59
▸ LMNA P02545 3/20 0.56
▸ TDP1 Q9NUW8 2/20 0.56
▸ CYP1A2 P05177 1/20 0.56
▸ MAPK1 P28482 1/20 0.54
▸ SMN1; SMN2 Q16637 3/20 0.53
▸ HTT P42858 3/20 0.53
▸ L3MBTL1 Q9Y468 1/20 0.53
▸ IDO1 P14902 1/20 0.53
▸ TDO2 P48775 1/20 0.53
▸ CA1 P00915 2/20 0.53
▸ CA2 P00918 2/20 0.53
▸ CA9 Q16790 2/20 0.53
▸ NPSR1 Q6W5P4 2/20 0.53
▸ MAPT P10636 5/20 0.53
▸ KDM4E B2RXH2 1/20 0.53
▸ CA12 O43570 1/20 0.52
▸ BRD4 O60885 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4118526 0.85 MAPT (0.66) MEN1KMT2AALDH1A1LMNAMAPK1
SCHEMBL21695331 0.84 ALDH1A1 (0.58) MEN1KMT2AALDH1A1LMNACYP1A2
SCHEMBL3714311 0.83 ALDH1A1 (0.66) MEN1KMT2AALDH1A1LMNAMAPK1
SCHEMBL6783366 0.83 GLA (0.71) MEN1KMT2AALDH1A1LMNATDP1
SCHEMBL10498193 0.83 MEN1 (0.54) MEN1KMT2AALDH1A1LMNATDP1
SCHEMBL9428604 0.83 POLB (0.57) MEN1KMT2AALDH1A1MAPK1SMN1; SMN2
SCHEMBL23624082 0.82 ALDH1A1 (0.56) MEN1KMT2AALDH1A1LMNAMAPK1
SCHEMBL18119753 0.82 ALDH1A1 (0.56) MEN1KMT2AALDH1A1LMNACYP1A2
SCHEMBL4117708 0.82 ALDH1A1 (0.61) MEN1KMT2AALDH1A1LMNAMAPK1
SCHEMBL7528148 0.81 ALDH1A1 (0.59) MEN1KMT2AALDH1A1LMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110487918-B Method for analyzing genotoxic impurities in pantoprazole sodium and initial raw material thereof 中国医学科学院药物研究所 2022-02-08 — — CN claimed
CN-110487918-A The analysis method of genotoxicity impurity in Pantoprazole Sodium and its starting material INST MATERIA MEDICA CAMS 2019-11-22 — — CN claimed
CN-102796021-B Method for synthesis of pantoprazole intermediate 4-difluoromethoxyacetanilide JIANGSU YUXIANG CHEMICAL CO., LTD. (CN) 2014-10-08 — — CN claimed
CN-103819409-A Preparation method of 5-difluoromethoxy-2-mercapto-1H-benzimidazole SHENYANG MANWEI CHEMICAL CO LTD 2014-05-28 — — CN claimed
CN-102796021-A Method for synthesis of pantoprazole intermediate 4-difluoromethoxyacetanilide JIANGSU YUXIANG CHEMICAL CO LTD 2012-11-28 — — CN claimed
CN-111615388-B Immunotherapeutic agent for cancer 斯汀格瑞治疗股份有限公司 2023-11-14 — — CN disclosed
CN-116848100-A NOTCH inhibitors and uses thereof 干细胞协同疗法有限责任公司 2023-10-03 — — CN disclosed
CN-210752646-U Vertical paddle type reaction kettle 马骅 2020-06-16 — — CN disclosed
US-9790169-B2 IDO inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2017-10-17 — — US disclosed
US-20170231999-A1 IDO INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-08-17 — — US disclosed
US-20160289171-A1 IDO INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2016-10-06 — — US disclosed
US-20150336866-A1 SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2015-11-26 — — US disclosed
EP-0166287-B1 DIALKOXYRIDINES, PROCESS FOR THEIR PREPARATION, THEIR APPLICATION AND MEDICAMENTS CONTAINING THEM Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1989-08-23 — — EP disclosed
US-4758579-A e.g. pantoprazole or pantoprazole sodium BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1988-07-19 — — US disclosed
US-4686230-A Picoline derivative useful as gastric acid secretion inhibitors BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1987-08-11 — — US disclosed
EP-0201575-A1 NEW PICOLINE DERIVATIVES, PREPARATION PROCESS THEREOF, UTILIZATION THEREOF AND DRUGS CONTAINING THEM. BYK GULDEN LOMBERG CHEM FAB (DE) 1986-11-20 — — EP disclosed
WO-1986002646-A1 NEW PICOLINE DERIVATIVES, PREPARATION PROCESS THEREOF, UTILIZATION THEREOF AND DRUGS CONTAINING THEM BYK GULDEN LOMBERG CHEMISCHE FABRIK GESELLSCHAFT M (DE) 1986-05-09 — — WO disclosed
EP-0166287-A1 Dialkoxyridines, process for their preparation, their application and medicaments containing them Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1986-01-02 — — EP disclosed
US-4555518-A ANTIULCER AGENTS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1985-11-26 — — US disclosed
EP-0134400-A2 Fluoroalkoxysubstituted pyridylmethylthio-(or sulfinyl-)benzimidazoles having a secretolytic activity Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1985-03-20 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170231999-A1 IDO INHIBITORS IDO1, IDO2, INMT MEN1 2981/4885KMT2A 461/4885ALDH1A1 707/4885
US-20150336866-A1 SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES DDT, ABL1, TYR MEN1 4119/4885KMT2A 829/4885ALDH1A1 3454/4885
US-20160289171-A1 IDO INHIBITORS IDO1, IDO2, INMT MEN1 2981/4885KMT2A 461/4885ALDH1A1 707/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.