Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19066702 | 0.67 | TAAR1 (0.56) | TAAR1SIGMAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12400987 | 0.67 | TP53 (0.48) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 | |
| SCHEMBL30934 | 0.67 | TRPA1 (0.77) | CYP2D6TRPA1TAAR1SIGMAR1SLC6A2 | |
| SCHEMBL5952618 | 0.67 | TSHR (0.41) | CYP2D6TRPA1TAAR1SIGMAR1SLC6A2 | |
| SCHEMBL555907 | 0.66 | CALM1 (0.50) | TRPA1TAAR1MAOACYP2A6TP53 | |
| SCHEMBL1140503 | 0.65 | TRPA1 (0.74) | CYP2D6TRPA1TAAR1SIGMAR1SLC6A2 | |
| Water SCHEMBL3896311 | 0.65 | TRPA1 (0.74) | CYP2D6TRPA1TAAR1SIGMAR1SLC6A2 | |
| SCHEMBL14114754 | 0.65 | SIGMAR1 (0.40) | CYP2D6TRPA1TAAR1SIGMAR1SLC6A2 | |
| SCHEMBL24101775 | 0.64 | LOXL2 (0.43) | CYP2D6TRPA1TAAR1SIGMAR1SLC6A2 | |
| SCHEMBL21063908 | 0.64 | TSHR (0.43) | TRPA1TAAR1SIGMAR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1762957-B | 2,3-dihydro-1-indene compound and preparation method thereof | BASELL POLYOLEFINE GMBH | 2010-05-12 | — | — | CN | disclosed |
| CN-100451024-C | Metallocene compound, indene compound and application thereof | BASELL POLYOLEFINE GMBH (DE) | 2009-01-14 | — | — | CN | disclosed |
| US-7038070-B2 | Preparation of preparing substituted indanones | BASELL POLYOLEFINE GMBH (DE) | 2006-05-02 | — | — | US | disclosed |
| CN-1762957-A | 2,3-dihydro-1-indene compound and preparation method thereof | BASELL POLYOLEFINE GMBH (DE) | 2006-04-26 | — | — | CN | disclosed |
| CN-1763060-A | Metallocene compound, indene compound and application thereof | BASELL POLYOLEFINE GMBH (DE) | 2006-04-26 | — | — | CN | disclosed |
| CN-1231431-C | Process for preparing substituted 2, 3-dihydro-1-indanones | TARGOR GMBH (DE) | 2005-12-14 | — | — | CN | disclosed |
| US-6963017-B2 | Preparation of preparing substituted indanones | BASELL POLYOLEFINE GMBH (DE) | 2005-11-08 | — | — | US | disclosed |
| EP-0968158-B1 | METHOD OF PREPARING SUBSTITUTED INDANONES, THE SUBSTITUTED INDANONES AND METALLOCENES PREPARED THEREFROM | BASELL POLYOLEFINE GMBH (DE) | 2005-08-10 | — | — | EP | disclosed |
| US-20050033076-A1 | Preparation of preparing substituted indanones | EQUISTAR CHEMICALS, LP | 2005-02-10 | — | — | US | disclosed |
| US-20030009046-A1 | Preparation of preparing substituted indanones | EQUISTAR CHEMICALS, LP | 2003-01-09 | — | — | US | disclosed |
| CN-1254328-A | Process for preparing substituted 2, 3-dihydro-1-indanones | TARGOR GMBH (DE) | 2000-05-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050033076-A1 | Preparation of preparing substituted indanones | CYP1A2, CYP2J2, IDH3A | CYP2D6 16/4885TRPA1 3969/4885TAAR1 3746/4885 |
| US-20030009046-A1 | Preparation of preparing substituted indanones | CYP1A2, CYP1B1, CYP1A1 | CYP2D6 15/4885TRPA1 3711/4885TAAR1 3272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.