Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.34 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.34 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4520012 | 0.78 | ENPP2 (0.32) | ORAI1ORAI2ORAI3ENPP2 | |
| SCHEMBL5951635 | 0.78 | ALDH1A1 (0.36) | ORAI1ORAI2ORAI3ADRB2ADRB1 | |
| SCHEMBL5952636 | 0.75 | TRPV6 (0.38) | ORAI1ORAI2ORAI3ENPP2HIF1A | |
| SCHEMBL16104430 | 0.74 | ENPP2 (0.45) | ORAI1ORAI2ORAI3ENPP2ALDH1A1 | |
| SCHEMBL17613263 | 0.71 | — | — | |
| SCHEMBL5951160 | 0.69 | CYP1A2 (0.33) | ALDH1A1MAPT | |
| SCHEMBL29404220 | 0.69 | TSHR (0.47) | ORAI1ORAI2ORAI3ENPP2ALDH1A1 | |
| SCHEMBL4129 | 0.69 | TSHR (0.47) | ORAI1ORAI2ORAI3ENPP2ALDH1A1 | |
| SCHEMBL31125058 | 0.69 | ENPP2 (0.39) | ORAI1ORAI2ORAI3ENPP2ADRB2 | |
| SCHEMBL27933411 | 0.69 | TSHR (0.38) | ORAI1ORAI2ORAI3ENPP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1762957-B | 2,3-dihydro-1-indene compound and preparation method thereof | BASELL POLYOLEFINE GMBH | 2010-05-12 | — | — | CN | disclosed |
| CN-100451024-C | Metallocene compound, indene compound and application thereof | BASELL POLYOLEFINE GMBH (DE) | 2009-01-14 | — | — | CN | disclosed |
| US-7038070-B2 | Preparation of preparing substituted indanones | BASELL POLYOLEFINE GMBH (DE) | 2006-05-02 | — | — | US | disclosed |
| CN-1762957-A | 2,3-dihydro-1-indene compound and preparation method thereof | BASELL POLYOLEFINE GMBH (DE) | 2006-04-26 | — | — | CN | disclosed |
| CN-1763060-A | Metallocene compound, indene compound and application thereof | BASELL POLYOLEFINE GMBH (DE) | 2006-04-26 | — | — | CN | disclosed |
| CN-1231431-C | Process for preparing substituted 2, 3-dihydro-1-indanones | TARGOR GMBH (DE) | 2005-12-14 | — | — | CN | disclosed |
| US-6963017-B2 | Preparation of preparing substituted indanones | BASELL POLYOLEFINE GMBH (DE) | 2005-11-08 | — | — | US | disclosed |
| EP-0968158-B1 | METHOD OF PREPARING SUBSTITUTED INDANONES, THE SUBSTITUTED INDANONES AND METALLOCENES PREPARED THEREFROM | BASELL POLYOLEFINE GMBH (DE) | 2005-08-10 | — | — | EP | disclosed |
| US-20050033076-A1 | Preparation of preparing substituted indanones | EQUISTAR CHEMICALS, LP | 2005-02-10 | — | — | US | disclosed |
| US-20030009046-A1 | Preparation of preparing substituted indanones | EQUISTAR CHEMICALS, LP | 2003-01-09 | — | — | US | disclosed |
| CN-1254328-A | Process for preparing substituted 2, 3-dihydro-1-indanones | TARGOR GMBH (DE) | 2000-05-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050033076-A1 | Preparation of preparing substituted indanones | CYP1A2, CYP2J2, IDH3A | ORAI1 4605/4885ORAI2 1642/4885ORAI3 2626/4885 |
| US-20030009046-A1 | Preparation of preparing substituted indanones | CYP1A2, CYP1B1, CYP1A1 | ORAI1 4577/4885ORAI2 1594/4885ORAI3 2480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.