Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.50 |
| ▸ | CHRNG | P07510 | 1/20 | 0.50 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | CHRND | Q07001 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5813245 | 0.86 | RAB9A (0.53) | SMN1; SMN2CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL5954545 | 0.85 | SLC6A3 (0.66) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL10469275 | 0.84 | HRH3 (0.49) | SMN1; SMN2CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL3424629 | 0.84 | ALDH1A1 (0.51) | PHGDHSMN1; SMN2CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL5953978 | 0.84 | SLC6A2 (0.68) | CHRNA1CHRNGCHRNB1CHRNB2SLC6A2 | |
| SCHEMBL321368 | 0.84 | ALDH1A1 (0.67) | SMN1; SMN2CHRNA1CHRNGCHRNB1CHRNB2 | |
| Hydrochloric Acid SCHEMBL9596868 | 0.83 | HRH3 (0.48) | SMN1; SMN2SLC6A3HRH3ALDH1A1TSHR | |
| SCHEMBL5954170 | 0.83 | MC4R (0.57) | SMN1; SMN2CHRNA1CHRNGCHRNB1CHRNB2 | |
| Hydrochloric Acid SCHEMBL10943241 | 0.83 | ALDH1A1 (0.65) | SMN1; SMN2CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL1696905 | 0.82 | ALDH1A1 (0.56) | SMN1; SMN2CHRNA1CHRNGCHRNB1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060058374-A1 | Urotensin II receptor agents | ACADIA PHARMACEUTICALS INC. | 2006-03-16 | — | — | US | disclosed |
| US-20040077529-A1 | Urotensin II receptor agents | ACADIA PHARMACEUTICALS, INC. | 2004-04-22 | — | — | US | disclosed |
| WO-2003104216-A1 | UROTENSIN II RECEPTOR MODULATORS | ACADIA PHARMACEUTICALS INC. (US) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077529-A1 | Urotensin II receptor agents | UTS2R, PLAUR, GPR17 | PHGDH 2681/4885SMN1; SMN2 2013/4885CHRNA1 1485/4885 |
| US-20060058374-A1 | Urotensin II receptor agents | UTS2R, PLAUR, SCTR | PHGDH 2616/4885SMN1; SMN2 2240/4885CHRNA1 1805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.