Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5955542 | 0.84 | CHRNA7 (0.33) | CHRM4CHRM2CHRM1HTR3ACHRNA7 | |
| SCHEMBL5954872 | 0.83 | CHRNA7 (0.31) | CHRM4CHRM2CHRM1HTR3ACHRNA7 | |
| SCHEMBL5955730 | 0.83 | CHRNA7 (0.38) | ALDH1A1HTR3ACHRNA7 | |
| SCHEMBL5954921 | 0.83 | CHRNA7 (0.38) | KDM1ACHRM4CHRM2CHRM1HTR3A | |
| SCHEMBL5376338 | 0.82 | CHRNA7 (0.46) | KDM1ACHRM2CHRM1HTR3ACHRNA7 | |
| SCHEMBL5955671 | 0.81 | ALDH1A1 (0.33) | ALDH1A1CHRNA7 | |
| SCHEMBL5955668 | 0.80 | CHRNA7 (0.36) | CHRM4EPHX2CHRM2CHRM1HTR3A | |
| SCHEMBL5955528 | 0.80 | EPHX2 (0.33) | KDM1ACHRM4NOTUMKDM2BHSD11B1 | |
| SCHEMBL5955750 | 0.80 | EBP (0.33) | CHRM4ALDH1A1EPHX2CHRM2CHRM1 | |
| SCHEMBL5954734 | 0.80 | PIK3CD (0.33) | KDM1ACHRM4HSD11B1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060116395-A1 | 1H-pyrazole and 1h-pyrole-azabicyclic compounds for the treatment of disease | PFIZER INC | 2006-06-01 | — | — | US | claimed |
| US-20040087616-A1 | 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease | PIOTROWSKI DAVID W (US) | 2004-05-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116395-A1 | 1H-pyrazole and 1h-pyrole-azabicyclic compounds for the treatment of disease | CYP7B1, P2RX7, CYP3A7 | KDM1A 652/4885CHRM4 528/4885ALDH1A1 426/4885 |
| US-20040087616-A1 | 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease | CYP1B1, TPMT, CYP7B1 | KDM1A 1440/4885CHRM4 4073/4885ALDH1A1 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.