Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5955986 | 0.83 | MRGPRX1 (0.49) | MRGPRX1 | |
| SCHEMBL13740900 | 0.78 | TSHR (0.48) | MRGPRX1LMNATSHRHTTSMN1; SMN2 | |
| SCHEMBL5956030 | 0.73 | FFAR4 (0.60) | MRGPRX1LMNATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL11614975 | 0.72 | LMNA (0.46) | MRGPRX1LMNATSHRHTTSMN1; SMN2 | |
| SCHEMBL5955997 | 0.71 | MEN1 (0.58) | HTTSMN1; SMN2MAPTKEAP1 | |
| SCHEMBL5762577 | 0.70 | ALDH1A1 (0.46) | LMNATSHRHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2061500 | 0.70 | ALDH1A1 (0.46) | LMNAARALDH1A1GAAMAPT | |
| SCHEMBL11573997 | 0.69 | ALDH1A1 (0.44) | LMNATSHRHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL763435 | 0.69 | ALDH1A1 (0.44) | LMNATSHRHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5955965 | 0.69 | PGR (0.56) | KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2006-01-05 | — | — | US | claimed |
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | SRC, LCK, ABL1 | MRGPRX1 1297/4885LMNA 4817/4885TSHR 3158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.