Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.43 |
| ▸ | TYK2 | P29597 | 7/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5956582 | 1.00 | JAK2 (0.43) | JAK2TYK2JAK1KCNMA1ROCK2 | |
| SCHEMBL5956665 | 0.90 | NAMPT (0.39) | JAK2TYK2KCNMA1SMN1; SMN2CYP17A1 | |
| SCHEMBL5956614 | 0.90 | NAMPT (0.39) | JAK2TYK2KCNMA1SMN1; SMN2CYP17A1 | |
| SCHEMBL5956481 | 0.88 | KCNMA1 (0.44) | JAK2TYK2KCNMA1CYP3A4MAPK1 | |
| SCHEMBL5956775 | 0.88 | KCNMA1 (0.44) | JAK2TYK2KCNMA1CYP3A4MAPK1 | |
| SCHEMBL5956667 | 0.84 | NAMPT (0.43) | CYP17A1MEN1KMT2ATDP1 | |
| SCHEMBL5956678 | 0.84 | NAMPT (0.43) | CYP17A1MEN1KMT2ATDP1 | |
| SCHEMBL5956617 | 0.82 | NFKB1 (0.37) | MEN1KMT2ATDP1 | |
| SCHEMBL5956623 | 0.82 | NFKB1 (0.37) | MEN1KMT2ATDP1 | |
| SCHEMBL5956660 | 0.82 | JAK2 (0.41) | JAK2TYK2JAK1KCNMA1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1270570-B1 | AMIDE COMPOUNDS AND USE THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-05-31 | — | — | EP | disclosed |
| US-6933305-B2 | Amide compounds and use thereof | MITSUBISHI PHARMA CORPORATION (JP) | 2005-08-23 | — | — | US | disclosed |
| US-20030158413-A1 | Amide compounds and use thereof | MITSUBISHI PHARMA CORPORATION (JP) | 2003-08-21 | — | — | US | disclosed |
| EP-1270570-A1 | AMIDE COMPOUNDS AND USE THEREOF | Mitsubishi Pharma Corporation (JP) | 2003-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158413-A1 | Amide compounds and use thereof | ROCK2, ROCK1, RHOT2 | JAK2 585/4885TYK2 354/4885JAK1 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.