Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12371428 | 0.79 | ROCK2 (0.37) | SMN1; SMN2TP53MAPTNPC1RAB9A | |
| SCHEMBL5956976 | 0.79 | F10 (0.45) | SMN1; SMN2LMNAF10KLKB1KMT2A | |
| SCHEMBL5956966 | 0.78 | F10 (0.44) | LMNAF10KLKB1KMT2APOLB | |
| SCHEMBL5956956 | 0.75 | F10 (0.61) | F10KMT2APOLB | |
| SCHEMBL5956933 | 0.75 | F10 (0.58) | SMN1; SMN2TP53MAPTNPC1RAB9A | |
| SCHEMBL5956923 | 0.74 | F10 (0.57) | SMN1; SMN2TP53MAPTNPC1RAB9A | |
| SCHEMBL12371426 | 0.74 | MEN1 (0.53) | MAPTNPC1RAB9ALMNAF10 | |
| SCHEMBL8471194 | 0.74 | MEN1 (0.53) | MAPTNPC1RAB9ALMNAF10 | |
| SCHEMBL8470830 | 0.74 | F10 (0.57) | MAPTF10KLKB1KMT2APOLB | |
| SCHEMBL12371425 | 0.74 | F10 (0.57) | MAPTF10KLKB1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633346-B1 | PYRROLIDIN-1, 2- DICARBOXYLIC ACID- 1- (4- ETHINYL- PHENYL) - AMID|- 2- (PHENYL)- AMID| DERIVATIVE AS INHIBITORS OF COAGULATION FACTOR XA AND VIIA FOR THE TREATMENT OF THROMBOSIS | MERCK PATENT GMBH (DE) | 2006-08-23 | — | — | EP | claimed |