Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957085 | 0.81 | DRD2 (0.44) | DRD2SLC6A4HTR2AHTR2BHDAC6 | |
| SCHEMBL5957093 | 0.80 | DRD2 (0.42) | DRD2SLC6A4HTR2AHTR2BDRD4 | |
| SCHEMBL5957135 | 0.80 | DRD2 (0.51) | DRD2DRD4DRD3 | |
| SCHEMBL5957067 | 0.78 | DRD2 (0.41) | DRD2SLC6A4HTR2AHTR2BDRD4 | |
| SCHEMBL5957097 | 0.78 | DRD2 (0.41) | DRD2SLC6A4HTR2AHTR2BDRD4 | |
| SCHEMBL5957079 | 0.77 | DRD2 (0.40) | DRD2SLC6A4HTR2AHTR2BDRD4 | |
| SCHEMBL5957055 | 0.76 | ALDH1A1 (0.55) | DRD2SLC6A4HTR2AHTR2BDRD4 | |
| SCHEMBL5957061 | 0.72 | MAPT (0.49) | DRD2SLC6A4HTR2AHTR2B | |
| SCHEMBL5957052 | 0.71 | DRD2 (0.41) | DRD2SLC6A4HTR2AHTR2BDRD4 | |
| SCHEMBL5957101 | 0.71 | DRD2 (0.41) | DRD2SLC6A4HTR2AHTR2BDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | claimed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | claimed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | claimed |
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | disclosed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |