Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 12/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957060 | 0.85 | MAPT (0.51) | MAPTHTR1ADRD2HTR2AHTR2B | |
| SCHEMBL5957055 | 0.82 | ALDH1A1 (0.55) | HTR1ADRD2HTR2AHTR2BHTR2C | |
| SCHEMBL5957117 | 0.80 | HTR1A (0.52) | MAPTHTR1ADRD2HTR2AHTR2B | |
| SCHEMBL5957135 | 0.78 | DRD2 (0.51) | DRD2MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL7828214 | 0.77 | MAPT (0.70) | MAPTHTR1AMEN1LMNATP53 | |
| SCHEMBL6991345 | 0.75 | CCR2 (0.43) | HTR1ADRD2HTR2ASLC6A4KMT2A | |
| SCHEMBL6319964 | 0.75 | MAPT (0.51) | MAPTHTR1ADRD2HTR2AHTR2B | |
| SCHEMBL7817707 | 0.74 | MAPT (0.68) | MAPTHTR1AMEN1LMNATP53 | |
| SCHEMBL5957093 | 0.74 | DRD2 (0.42) | MAPTDRD2HTR2AHTR2BSLC6A4 | |
| SCHEMBL7827977 | 0.74 | MAPT (0.57) | MAPTHTR1AMEN1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | claimed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | claimed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | claimed |
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | disclosed |